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Titolo:
Risk factors associated with fetal losses in treated antiphospholipid syndrome pregnancies: A multivariate analysis
Autore:
Carmona, F; Font, J; Azulay, M; Creus, M; Fabregues, F; Cervera, R; Puerto, B; Balasch, J;
Indirizzi:
Univ Barcelona, Inst Invest Biomed, Hosp Clin, Inst Clin Gynecol Obstet & Neonatol, Barcelona 08036, Spain Univ Barcelona Barcelona Spain 08036 & Neonatol, Barcelona 08036, Spain Univ Barcelona, Fac Med, Hosp Clin,System Autoimmune Dis Unit, Inst InvestBiomed August Pi & Sunyer, Barcelona 08036, Spain Univ Barcelona Barcelona Spain 08036 Pi & Sunyer, Barcelona 08036, Spain
Titolo Testata:
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
fascicolo: 4, volume: 46, anno: 2001,
pagine: 274 - 279
SICI:
1046-7408(200110)46:4<274:RFAWFL>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DOSE ASPIRIN; RECURRENT MISCARRIAGE; ANTIBODY SYNDROME; WOMEN; PREVENTION; CRITERIA; UTERINE; DEATH;
Keywords:
antiphospholipid syndrome; pregnancies; fetal outcome; obstetric complications; risk factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Balasch, J Univ Barcelona, Fac Med, Hosp Clin, Inst Clin Gynecol Obstet & Neonatol, CCasanova 143, Barcelona 08036, Spain Univ Barcelona C Casanova 143 Barcelona Spain 08036 036, Spain
Citazione:
F. Carmona et al., "Risk factors associated with fetal losses in treated antiphospholipid syndrome pregnancies: A multivariate analysis", AM J REPROD, 46(4), 2001, pp. 274-279

Abstract

PROBLEM: Pregnancies in women with antiphospholipid syndrome (APS) are associated with obstetric complications despite treatment. The present study analyzes risk factors and evaluates fetal outcome in a large sample of treated APS pregnancies. METHOD OF STUDY: Seventy-seven pregnancies in 56 women were included. Twelve selected variables potentially related to the outcome of treated pregnancies were analyzed in a multivariate logistic regression model. RESULTS: Treated women delivered 65 live infants at 24-41 weeks gestation (mean 36.7 +/- 0.5) but two neonatal deaths occurred. There were seven first-trimester miscarriages (9%) and five intrauterine fetal demises (6.5%). Thus, the probability of having a live baby under treatment was 82% (95% CI 71.3-89.6%), a figure significantly greater (P<0.001) than that observed before therapy (25.7%; 95% CI 18.7-33.7%). Variables related with fetal outcome in the multivariate model were: preconceptional use of aspirin and abnormal umbilical artery Doppler velocimetry at 23-26 weeks gestation. CONCLUSIONS: The present report shows that in treated APS pregnancies: i) aspirin treatment started preconceptionally is an independent and significant prognostic factor associated with favorable fetal outcome; and ii) abnormal velocity waveforms in the umbilical artery predict adverse outcome of pregnancy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:53:50