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Titolo:
Electrophysiological evidence of serotonergic impairment in long-term MDMA("ecstasy") users
Autore:
Croft, RJ; Klugman, A; Baldeweg, T; Gruzelier, JH;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Cognit Neurosci& Behav, London W6 8RF, England Univ London Imperial Coll Sci Technol & Med London England W6 8RF ngland
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 10, volume: 158, anno: 2001,
pagine: 1687 - 1692
SICI:
0002-953X(200110)158:10<1687:EEOSII>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUDITORY-EVOKED POTENTIALS; 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; (+/-)3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; COGNITIVE PERFORMANCE; INTENSITY DEPENDENCE; MEMORY DEFICITS; RAT-BRAIN; MOOD; NEURONS; HUMANS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Gruzelier, JH Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Cognit Neurosci& Behav, St Dunstans Rd, London W6 8RF, England Univ London Imperial Coll Sci Technol & Med St Dunstans Rd London England W6 8RF
Citazione:
R.J. Croft et al., "Electrophysiological evidence of serotonergic impairment in long-term MDMA("ecstasy") users", AM J PSYCHI, 158(10), 2001, pp. 1687-1692

Abstract

Objective: "Ecstasy," or 3,4-methylenedioxymethamphetamine (MDMA), causes long-term impairment to the serotonin (5-HT) system in rats, dogs, and nonhuman primates. 5-HT dysfunction has also been observed in human recreational users of the drug, but whether 5-HT dysfunction in humans is caused by MDMA has not been established, since dysfunction may have preceded MDMA exposure This ambiguity about causation is particularly important in MDMA research, because 5-HT deficiency is a predictor of risky behavior. Method: The 5-HT function of 22 longterm MDMA users was compared to that of 20 drug-naive comparison subjects and 19 cannabis users. 5-HT function was assessed with the intensity dependence paradigm, a tool that measures 5-HT-related attenuation of neural response to auditory stimuli (measured withEEG). Results: Long-term MDMA users exhibited 5-HT dysfunction, relative to bothcannabis users and drug-naive comparison subjects. This dysfunction was related to total MDMA consumption (after removing the effect of frequency of use) but not to frequency of use (after removing the effect of total consumption). Conclusions: These data show that 5-HT dysfunction occurs in MDMA users, is related to users' MDMA consumption, and is independent of cannabis use. The results do not suggest that self-medication explains this relationship, because the deficit was related to total MDMA consumption but not frequencyof consumption. The results are thus consistent with the thesis that MDMA consumption causes 5-HT impairment in humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:23:19