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Titolo:
Maternal sertraline treatment and serotonin transport in breast-feeding mother-infant pairs
Autore:
Epperson, N; Czarkowski, KA; Ward-OBrien, D; Weiss, E; Gueorguieva, R; Jatlow, P; Anderson, GM;
Indirizzi:
Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06511 USA Yale Univ New Haven CT USA 06511 , Dept Psychiat, New Haven, CT 06511 USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 10, volume: 158, anno: 2001,
pagine: 1631 - 1637
SICI:
0002-953X(200110)158:10<1631:MSTAST>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR DEPRESSIVE DISORDER; H-3 IMIPRAMINE BINDING; PLATELET SEROTONIN; HUMAN-MILK; ANTIDEPRESSANT DRUGS; NURSING INFANTS; 5-HT CONTENT; FLUOXETINE; EXCRETION; PAROXETINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Epperson, N Yale Univ, Sch Med, Dept Psychiat, Univ Towers,Suite 2H,100 York St, New Haven, CT 06511 USA Yale Univ Univ Towers,Suite 2H,100 York St New Haven CT USA 06511
Citazione:
N. Epperson et al., "Maternal sertraline treatment and serotonin transport in breast-feeding mother-infant pairs", AM J PSYCHI, 158(10), 2001, pp. 1631-1637

Abstract

Objective: Pharmacological treatment of postpartum depression is frequently complicated by the mother's desire to breastfeed. Although breast milk levels of several selective serotonin reuptake inhibitors (SSRIs) have been reported to be relatively low, a critical question is whether SSRI exposure during nursing results in clinically significant blockade of serotonin (5-HT) reuptake in infants. This study determined the degree of transporter blockade in infants exposed to sertraline through maternal breast milk. Method: The extent of maternal and infant transporter blockade was assessed by measurement of platelet levels of 5-HT in 14 breast-feeding mother-infant pairs before and after 6-16 weeks of maternal treatment with sertralinefor major depression with postpartum onset. Plasma sertraline and desmethylsertraline levels were obtained in 13 of these mothers and 11 of their infants. Results: Marked declines in platelet 5-HT levels of 70%-96% were observed in mothers after sertraline treatment, 25-200 mg/day. In contrast, infants showed little or no change in platelet 5-HT levels after exposure through breast-feeding. Mean levels of maternal plasma sertraline and its major metabolite, desmethylsertraline, were 30.7 ng/ml and 45.3 ng/ml, respectively. Drug and drug metabolite concentrations in the infants were at or below thelower limit of quantitation. Conclusions: The data indicate that while mothers receiving clinical dosesof sertraline experience substantial blockade of the platelet 5-HT transporter, platelet 5-HT uptake in nursing infants of treated mothers is unaltered. The observations suggest that mothers taking sertraline can breast-feedwithout appreciably affecting peripheral or central 5-HT transport in their infants.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:19:15