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Titolo:
Association of transforming growth factor-beta 1 T29C polymorphism with the progression of diabetic nephropathy
Autore:
Akai, Y; Sato, H; Ozaki, H; Iwano, M; Dohi, Y; Kanauchi, M;
Indirizzi:
Nara Med Univ, Dept Internal Med 1, Dept Publ Hlth, Kashihara, Nara 6348522, Japan Nara Med Univ Kashihara Nara Japan 6348522 Kashihara, Nara 6348522, Japan
Titolo Testata:
AMERICAN JOURNAL OF KIDNEY DISEASES
fascicolo: 4, volume: 38, anno: 2001, supplemento:, 1
pagine: S182 - S185
SICI:
0272-6386(200110)38:4<S182:AOTGF1>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA-1 GENE; MYOCARDIAL-INFARCTION; FACTOR-BETA;
Keywords:
transforming growth factor-beta 1 (TGF-beta 1); polymorphism; diabetic nephropathy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Akai, Y Nara Med Univ, Dept Internal Med 1, Dept Publ Hlth, 840 Shijo, Kashihara, Nara 6348522, Japan Nara Med Univ 840 Shijo Kashihara Nara Japan 6348522 348522, Japan
Citazione:
Y. Akai et al., "Association of transforming growth factor-beta 1 T29C polymorphism with the progression of diabetic nephropathy", AM J KIDNEY, 38(4), 2001, pp. S182-S185

Abstract

Diabetes mellitus Is a leading cause of end-stage renal disease in the Western world. Histologically, mesangial expansion with increased extracellular matrix protein Is observed In patients with diabetic nephropathy. Becausetransforming growth factor (TGF)-beta promotes extracellular matrix production in response to high glucose, TGF-beta Is considered to play a central role in the pathogenesis of diabetic nephropathy. We investigated the association of TGF-beta1 T29C polymorphism and the progression of diabetic nephropathy. Forty patients with type 2 diabetes mellitus were enrolled. All patients had had diabetes for more than 10 years. DNA was extracted from peripheral blood cells, and genotype was determined using real-time polymerase chain reaction method. Patients were classified Into three groups according to genotype: TT, TC, and CC. Grade of diabetic nephropathy was determined using the amount of urinary excretion of albumin. Demographic characteristics of the patients with each genotype were not statistically different. No differences In the glycemic control and the mode of therapy were observed. Among patients with three genotypes, the severity of diabetic nephropathy was not statistically different. The patients with TT genotype tended to havea higher rate of progression of nephropathy; however, no statistically significant difference was observed among the three groups. Our results suggest that TGF-beta1 T29C polymorphism Is not associated with the progression of diabetic nephropathy. Further studies are required to determine the exactrole of this polymorphism In the progression of diabetic nephropathy. (C) 2001 by the National Kidney Foundation, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:28:55