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Titolo:
Ultrashort regimen of lansoprazole-amoxicillin-azithromycin for eradicating Helicobacter pylori
Autore:
Chahine, C; Moukhachen, O; Chedid, M; Araj, GF; Sharara, AI;
Indirizzi:
Amer Univ Beirut, Med Ctr, Dept Internal Med, Beirut, Lebanon Amer Univ Beirut Beirut Lebanon Ctr, Dept Internal Med, Beirut, Lebanon Amer Univ Beirut, Med Ctr, Dept Pathol & Lab Med, Beirut, Lebanon Amer Univ Beirut Beirut Lebanon Dept Pathol & Lab Med, Beirut, Lebanon Lebanese Amer Univ, Sch Pharm, Byblos, Lebanon Lebanese Amer Univ ByblosLebanon Amer Univ, Sch Pharm, Byblos, Lebanon
Titolo Testata:
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
fascicolo: 19, volume: 58, anno: 2001,
pagine: 1819 - 1823
SICI:
1079-2082(20011001)58:19<1819:UROLFE>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
OMEPRAZOLE PLUS AMOXICILLIN; DOSE TRIPLE THERAPY; DUODENAL-ULCER; CONTROLLED TRIAL; DUAL-THERAPY; DOUBLE-BLIND; INFECTION; CLARITHROMYCIN; CURE; METRONIDAZOLE;
Keywords:
amoxicillin trihydrate; azithromycin; combined therapy; dosage schedules; gastrointestinal drugs; helicobacter infections; lansoprazole; macrolides; penicillins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Sharara, AI Amer Univ Beirut, Med Ctr, Dept Internal Med, POB 11-0236-16-B, Beirut, Lebanon Amer Univ Beirut POB 11-0236-16-B Beirut Lebanon ut, Lebanon
Citazione:
C. Chahine et al., "Ultrashort regimen of lansoprazole-amoxicillin-azithromycin for eradicating Helicobacter pylori", AM J HEAL S, 58(19), 2001, pp. 1819-1823

Abstract

The efficacy and safety of two ultrashort azithromycin-containing regimensfor Helicobacter pylori infection were studied. Patients positive for H. pylori infection were assigned to receive either a three-day drug regimen (group A) or a five-day regimen (group B). In bothgroups, patients received lansoprazole 30 mg p.o. twice daily on day 1 and, on days 2 and 3, lansoprazole 30 mg p.o. twice daily, amoxicillin 1 g (ofanhydrous amoxicillin) p.o. twice daily, and azithromycin 500 mg (of anhydrous azithromycin) p.o. twice daily. Group B patients received lansoprazole30 mg p.o. twice daily and amoxicillin 1 g p.o. twice daily for two additional days. Gastric biopsy specimens were subjected to culture and susceptibility testing. A minimum of four weeks after the completion of therapy, thepatients underwent a C-14-urea breath test to determine whether H. pylori had been eradicated. A total of 28 patients were enrolled (15 in group A and 13 in group B). Treatment was well tolerated. H. pylori was eradicated in 4 (36%) of 11 patients in group A and 2 (22%) of 9 group B patients (26.6% and 15.4%, respectively, in intention-to-treat analysis). None of the isolates of H. pylori showed resistance to amoxicillin or clarithromycin. Regimens consisting of lansoprazole plus two or four days of azithromycin and amoxicillin therapy eradicated H. pylori in 36% and 22% of patients, respectively.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 06:49:47