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Titolo:
Hematocrit and the risk of coronary heart disease mortality
Autore:
Brown, DW; Giles, WH; Croft, JB;
Indirizzi:
CDCP, Cardiovasc Hlth Branch, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA CDCP Atlanta GA USA Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA
Titolo Testata:
AMERICAN HEART JOURNAL
fascicolo: 4, volume: 142, anno: 2001,
pagine: 657 - 663
SICI:
0002-8703(200110)142:4<657:HATROC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATIONAL DEATH INDEX; INTIMA-MEDIA THICKNESS; BLOOD-VISCOSITY; ARTERY DISEASE; CARDIOVASCULAR RISK; CELL-PROLIFERATION; PLASMA VISCOSITY; EDINBURGH ARTERY; UNSTABLE ANGINA; YOUNG-WOMEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Giles, WH CDC, Cardiovasc Hlth Branch, NCCDPHP, MS K-47,4770 Buford Hwy NE, Atlanta,GA 30341 USA CDC MS K-47,4770 Buford Hwy NE Atlanta GA USA 30341 GA 30341 USA
Citazione:
D.W. Brown et al., "Hematocrit and the risk of coronary heart disease mortality", AM HEART J, 142(4), 2001, pp. 657-663

Abstract

Background An association between hematocrit (Hct) and coronary heart disease (CHD) mortality has been previously observed. However, the relationshipof Hct and CHID independent of other cardiovascular disease (CVD) risk factors and differences between men and women remain unclear. Methods We examined the association between Hct and CHD mortality with Coxregression analyses of data from 8896 adults, aged 30-75 years, in the Second National Health and Nutrition Examination Survey (NHANES II) Mortality Study (1976-1992). Covariates included age, sex, race, education, smoking status, hypertensive status, total serum cholesterol, body mass index, whiteblood cell count, and history of CVD and diabetes. Hct was categorized by use of sex-specific tertiles, and all analyses were stratified by sex. Results During 16.8 years of follow-up, there were 545 (men 343, women 202) deaths from CHD (international Classification of Diseases, 9th revision [ICD-9] 410-414), 778 (men 426, women 279) deaths from diseases of the heart(ICD-9 390-398, 402, 404, 410-414, 415-417, 420-429), and 2046 (men 1216, women 830) all-cause deaths. Among men, the crude CHD mortality rate per 10,000 population was 42.6, 31.9, and 46.3 among those with Hct in the lower,middle, and upper tertiles, respectively. The corresponding crude CHD mortality rates among women were 12.6, 18.6, and 27.7. After adjustment for ageand other CVD risk factors, there was no association between Hct in the upper tertile compared with the lower tertile and mortality from either CHD, diseases of the heart, or all causes among men. Women with Hct in the uppertertile were 1.3 times (95% Cl 0.9-1.9) more likely to die from CHD than were women with Hct in the lowest tertile, after multivariate adjustment. The effect of high Hct on CHD mortality among women younger than 65 years of age was slightly stronger (relative risk 2.2, 95% Cl 1.0-4.6). Conclusions These results suggest that the association between Hct and mortality from CHD and all causes is complex, differing both by sex and age. Further research is needed to gain a better understanding of these age and sex differences.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 02:24:19