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Titolo:
The effects of different levels of dietary restriction on aging and survival in the Sprague-Dawley rat: Implications for chronic studies
Autore:
Duffy, PH; Seng, JE; Lewis, SM; Mayhugh, MA; Aidoo, A; Hattan, DG; Casciano, DA; Feuers, RJ;
Indirizzi:
US FDA, Natl Ctr Toxicol Res, Div Genet & Reprod Toxicol, Jefferson, AR 72079 USA US FDA Jefferson AR USA 72079 t & Reprod Toxicol, Jefferson, AR 72079 USA
Titolo Testata:
AGING-CLINICAL AND EXPERIMENTAL RESEARCH
fascicolo: 4, volume: 13, anno: 2001,
pagine: 263 - 272
SICI:
0394-9532(200108)13:4<263:TEODLO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC CALORIC RESTRICTION; FISCHER-344 RATS; MAMMARY-TUMORS; PATHOLOGY; TOXICITY; VARIABILITY; VARIABLES; MICE;
Keywords:
aging; chronic; dietary restriction; survival; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Duffy, PH US FDA, Natl Ctr Toxicol Res, Div Genet & Reprod Toxicol, 3900 NCTR Rd, Jefferson, AR 72079 USA US FDA 3900 NCTR Rd Jefferson AR USA 72079 fferson, AR 72079 USA
Citazione:
P.H. Duffy et al., "The effects of different levels of dietary restriction on aging and survival in the Sprague-Dawley rat: Implications for chronic studies", AGING-CLIN, 13(4), 2001, pp. 263-272

Abstract

A study was undertaken to determine the effects of incremental levels of dietary restriction (DR) in rats. Survival, growth, reproductive, and dietary intake (DI) variables were monitored in a chronic study in which male Sprague Dawley (SD) rats (NCTR colony) were fed their ration ad libitum (AL), or DR. The main objectives were to determine if low levels of DR could be used to increase the survival rate of SD rats in the chronic bioassay, and to identify the survival characteristics of a long-lived SD rat strain (NCTRcolony). The average life span of AL rats was 115 months. At 104 weeks on study (110 weeks of age), the survival rate for the AL and 10%, 25%, and 40% DR groups was 63.4, 87.5, 87.5, and 97.5%, respectively. The largest increase in survival (24.1%) occurred between AL and 10% DR, indicating that very low levels of DR have a significant effect on survival. Whole-body, liver, prostate, and epididymis weights and body length were decreased by DR, whereas brain weight, testicular weight, and skull length were not altered by DR. Rats from the NCTR colony were found to be ideal for chronic studies because they are much longer-lived than other SD stocks. Although the 104-week survival rate for these SD, non-obese AL rats exceeds the FDA's "Redbook" survival guideline (> 50%) for chronic bioassays, the use of DR is advocated because it reduces individual variability in body weight. (C) 2001, Editrice Kurtis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 18:43:30