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Titolo:
Signaling pathway mediated by ic-opioid receptor is impaired in cardiac hypertrophy
Autore:
Pei, JM; Wang, YM; Zhu, YL; Chen, M; Wong, TM;
Indirizzi:
Fourth Mil Med Univ, Xijin Hosp, Dept Physiol, Xian 710032, Peoples R China Fourth Mil Med Univ Xian Peoples R China 710032 710032, Peoples R China Fourth Mil Med Univ, Xijin Hosp, Dept Cardiol, Xian 710032, Peoples R China Fourth Mil Med Univ Xian Peoples R China 710032 710032, Peoples R China Univ Hong Kong, Fac Med, Inst Cardiovasc Sci & Med, Dept Physiol, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples RChina Kong, Peoples R China
Titolo Testata:
ACTA PHARMACOLOGICA SINICA
fascicolo: 10, volume: 22, anno: 2001,
pagine: 887 - 895
SICI:
0253-9756(200110)22:10<887:SPMBIR>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; NA+-H+ EXCHANGE; VENTRICULAR MYOCYTES; RAT-HEART; STIMULATION; CA2+; PH; INVOLVEMENT; CELLS; CA-2+;
Keywords:
cardiomegaly; kappa opioid receptors; protein kinase C; calcium; sodium-hydrogen antiporter;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Pei, JM Fourth Mil Med Univ, Xijin Hosp, Dept Physiol, Xian 710032, Peoples R China Fourth Mil Med Univ Xian Peoples R China 710032 Peoples R China
Citazione:
J.M. Pei et al., "Signaling pathway mediated by ic-opioid receptor is impaired in cardiac hypertrophy", ACT PHAR SI, 22(10), 2001, pp. 887-895

Abstract

Aim: The responses of the intracellular calcium ([Ca2+](i)) and the intracellular pH (pH(i)) to kappa -opioid receptor stimulation were determined inthe single right ventricular myocytes isolated from the hearts of chronically hypoxic rats which exhibited right ventricular hypertrophy (RVH). Methods: With the spectrofluorometric method, the electrically-induced [Ca2+](i)transient and pH(i) were measured in myocytes loaded with fura-2 and BCECF[2', 7-bis- (2-carboxyethyl)-5-(and 6)-carboxyfluorscein], respectively. Results: U50,488H, a selective kappa -opioid agonist decreased the electrically-induced [Ca2+](i) transient and increased the pH(i). The effect of U50,488H was mediated by protein kinase C(PKC). In the RVH, the effect of U50,488H on the [Ca2+](i) transient and the pH(i) were significantly attenuated. In parallel, 4-phorbol 12-myristate 13-acetate (PMA), an activator of PKC, also decreased the [Ca2+](i) transient and increased the pH(i). In the RVH, the effects of PMA were blunted. The recovery of pH(i), which was blocked by ethylisopropyl-amifloride (EIPA), following an acid loading induced by washout of 10 mmol/L NH4Cl exposing to the cells for 10 min was the same in the RVH and control myocytes. Conclusion: kappa -Opioid receptor signaling was impaired in the cardiac hypertrophy due to a defect in the coupling of PKC signaling with its effector.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:38:24