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Titolo:
Progesterone receptor status and tumor size as possible indicators of axillary lymph node involvement in T1 carcinoma of the breast
Autore:
Ron, IG; Kovner, F; Lifschitz-Mercer, B; Inbar, MJ;
Indirizzi:
Tel Aviv Univ, Tel Aviv Soursky Med Ctr, Dept Oncol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 Oncol, IL-69978 Tel Aviv, Israel Tel Aviv Univ, Tel Aviv Soursky Med Ctr, Dept Pathol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 Pathol, IL-69978 Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 ac Med, IL-69978 Tel Aviv, Israel
Titolo Testata:
ACTA ONCOLOGICA
fascicolo: 5, volume: 40, anno: 2001,
pagine: 629 - 632
SICI:
0284-186X(2001)40:5<629:PRSATS>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIVARIATE-ANALYSIS; CANCER; DISSECTION; SURVIVAL; PROGNOSIS; MANAGEMENT; METASTASES; MORBIDITY; SURGERY; IMPACT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Ron, IG Tel Aviv Univ, Tel Aviv Soursky Med Ctr, Dept Oncol, 6 Weizman St,IL-69978 Tel Aviv, Israel Tel Aviv Univ 6 Weizman St Tel Aviv Israel IL-69978 Aviv, Israel
Citazione:
I.G. Ron et al., "Progesterone receptor status and tumor size as possible indicators of axillary lymph node involvement in T1 carcinoma of the breast", ACTA ONCOL, 40(5), 2001, pp. 629-632

Abstract

Disagreement persists on the necessity of axillary lymph node dissection for small T1 stage unilateral breast cancers. In this study of 120 women with T1 primary tumors who underwent extensive dissection, better definition of pathological factors that can predict axillary node metastases might havespared 88 (73.3%) who were node negative. We assessed age, tumor size, histology, grade and hormone receptor status as possible indicators of lymph node involvement. As expected, tumor size was a strong predictor of the likelihood of node involvement (p = 0.026 in univariate and p = 0.0024 in multivariate analyses). Progesterone receptor status also correlated significantly (p = 0.0008 in univariate and p = 0.017 in multivariate analyses) with axillary positivity. Tumor grade was found to be significant (p = 0.018) only in univariate analysis. These findings contribute to the ongoing search for confident selection of subgroups of patients who will undergo lumpectomybut can safely be spared axillary node dissection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 10:07:10