Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Medical treatment of endocrine ophtalmopathy: "State of the art"
Autore:
Weissel, M;
Indirizzi:
Univ Vienna, Innere Med Klin 3, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 ere Med Klin 3, A-1090 Vienna, Austria Ludwig Boltzmann Inst Nucl Med & Endocrinol, Vienna, Austria Ludwig Boltzmann Inst Nucl Med & Endocrinol Vienna Austria nna, Austria
Titolo Testata:
ACTA MEDICA AUSTRIACA
fascicolo: 4, volume: 28, anno: 2001,
pagine: 93 - 96
SICI:
0303-8173(2001)28:4<93:MTOEO">2.0.ZU;2-F
Fonte:
ISI
Lingua:
GER
Soggetto:
THYROID-ASSOCIATED OPHTHALMOPATHY; SEVERE GRAVES OPHTHALMOPATHY; PULSE THERAPY; PREDNISONE; PENTOXIFYLLINE; CYCLOSPORINE; RETROBULBAR; DISEASE; TRIAL;
Keywords:
endocrine ophtalmopathy; glucocorticoids; cyclosporin; immunoglobulins; pentoxifyllin; methotrexat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Weissel, M Univ Vienna, Innere Med Klin 3, Waehringer Guertel 18, A-1090 Vienna, Austria Univ Vienna Waehringer Guertel 18 Vienna Austria A-1090 ustria
Citazione:
M. Weissel, "Medical treatment of endocrine ophtalmopathy: "State of the art"", ACT MED AUS, 28(4), 2001, pp. 93-96

Abstract

This review describes the state of the art of the conservative therapeutical approach of thyroid associated eye disease. Radiotherapy, surgery and ablative therapy of thyroid ophtalmopathy are discussed elsewhere in this issue of Acta Med Austriaca. All forms of therapy have to be adjusted to the severeness of the eye disease. The assessment of the severeness of this ailment can be difficult. Therefore, the impact of scoring systems like the "Clinical Activity Score" is pointed out. Treatment of thyroid dysfunction is the widely accepted first therapeutic measure. Additional supportive local therapy is usually sufficient in patients with only mild activity of endocrine ophtalmopathy. Glucocorticoids applied via different routes in various dose regimens are the therapy of first choice in (moderately) severe forms of the disease. Reported response rates for the oral form of therapy are about 63 %, for the intravenously applied very high doses (given only in verysevere forms of the disease) nearly 77 %. Cyclosporin has been shown to bemore efficient in combination with oral glucocorticoids in patients with moderately severe eye disease than glucocorticoids alone. Patients need a close follow up since both drugs have considerable side effects. An alternative treatment with highdose intravenous immunoglobulins seems to have less side effects, but has the disadvantage of bearing the danger of serious infections as all plasma derived products and of being extremely expensive. Finally, preliminary data of new treatment modalities with the immunomodulators pentoxifyllin and methotrexat are presented. These drugs have been testedso far with good success in patients with severe endocrine ophtalmopathy and unresponsive to other forms of treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 10:28:54