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Titolo:
Procalcitonin as a diagnostic marker in patients with aspiration after closed head injury
Autore:
Pusch, F; Wildling, E; Freitag, H; Weinstabl, C;
Indirizzi:
Univ Vienna, Dept Anesthesiol & Gen Intens Care, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 en Intens Care, A-1090 Vienna, Austria Gen Hosp, Dept Anesthesiol & Gen Intens Care, Korneuburg, Austria Gen Hosp Korneuburg Austria siol & Gen Intens Care, Korneuburg, Austria
Titolo Testata:
WIENER KLINISCHE WOCHENSCHRIFT
fascicolo: 17-18, volume: 113, anno: 2001,
pagine: 676 - 680
SICI:
0043-5325(20010917)113:17-18<676:PAADMI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; C-REACTIVE PROTEIN; GLASGOW COMA SCALE; SERUM PROCALCITONIN; CALCITONIN; PNEUMONIA; MORTALITY; SEPSIS; LUNG;
Keywords:
closed head injury; procalcitonin; aspiration; prognostic; C-reactive protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Pusch, F Univ Vienna, Dept Anesthesiol & Gen Intens Care, Waehringer Guertel 18-20,A-1090 Vienna, Austria Univ Vienna Waehringer Guertel 18-20 Vienna Austria A-1090 stria
Citazione:
F. Pusch et al., "Procalcitonin as a diagnostic marker in patients with aspiration after closed head injury", WIEN KLIN W, 113(17-18), 2001, pp. 676-680

Abstract

Background: Aspiration of gastric content frequently induces early onset of pneumonia in patients with impaired consciousness after closed head injury and thus worsens the prognosis. Early detection of aspiration and appropriate therapy are essential. The purpose of the study was to assess the diagnostic value of procalcitonin (ProCT) in aspiration of gastric content and to evaluate its prognostic impact in patients with closed head injury. Methods: Twenty-three patients with isolated closed head injury (Glasgow Coma Scale [GCS] score less than or equal to 8) were studied. Bronchoscopy was done on admission; chest radiographs and routine laboratory examination including C-reactive protein were performed daily. ProCT was analyzed 12, 24, 36 and 72 hours after trauma using an immunoluminometric assay. Results: ProCT was higher throughout the study period in 9 patients with persistent radiological signs suspect for aspiration of gastric content and there was evidence of aspiration of gastric content during bronchoscopy on admission. Median ProCT values of 1.397 ng/ml (range, 0.372 to 8.358 ng/ml)on admission increased to 2.144 ng/ml (range, 0.716 to 6.910 ng/ml) 24 hours after trauma, and then decreased to baseline values of 1.711 ng/ml (range, 0.611 to 6.639 ng/ml) as early as 36 hours after trauma. In patients without signs of aspiration of gastric content, ProCT values did not exceed 0.418 ng/ml. Non-survivors had higher serum levels of ProCT throughout the study period. Conclusion: Our findings suggest that ProCT is a useful diagnostic marker for detecting aspiration of gastric content while the prognostic value of ProCT for predicting survival after isolated closed head injury was moderate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 10:14:22