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Titolo:
The ACVD task force on canine atopic dermatitis (XXI): antihistamine pharmacotherapy
Autore:
DeBoer, DJ; Griffin, CE;
Indirizzi:
Univ Wisconsin, Sch Vet Med, Dept Med Sci, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 , Dept Med Sci, Madison, WI 53706 USA Anim Dermatol Clin, San Diego, CA USA Anim Dermatol Clin San Diego CA USA nim Dermatol Clin, San Diego, CA USA
Titolo Testata:
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
fascicolo: 3-4, volume: 81, anno: 2001,
pagine: 323 - 329
SICI:
0165-2427(20010920)81:3-4<323:TATFOC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIINFLAMMATORY AGENTS; ANTIALLERGIC ACTIVITY; HYPERSENSITIVE DOGS; ANTIPRURITIC AGENT; HISTAMINE-RELEASE; MAST-CELLS; TERFENADINE; PRURITUS; MANAGEMENT; CETIRIZINE;
Keywords:
antihistamine; atopy; dog; dermatitis; hypersensitivity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: DeBoer, DJ Univ Wisconsin, Sch Vet Med, Dept Med Sci, 2015 Linden Dr, Madison, WI 53706 USA Univ Wisconsin 2015 Linden Dr Madison WI USA 53706 WI 53706 USA
Citazione:
D.J. DeBoer e C.E. Griffin, "The ACVD task force on canine atopic dermatitis (XXI): antihistamine pharmacotherapy", VET IMMUNOL, 81(3-4), 2001, pp. 323-329

Abstract

Antihistamines frequently are recommended by veterinary dermatologists forsymptomatic treatment of pruritus associated with canine atopic dermatitis(AD), perhaps because of their moderate success in some human patients with AD. A critical review of the literature describing antihistamine use in canine AD reveals that the majority of published, peer-reviewed studies are open, uncontrolled or partially-controlled trials. Such studies vary widelyin reported efficacy, from perhaps 0 to 75% of patients, even using the same drug. The few blinded placebo-controlled trials available have failed toconfirm efficacy of these drugs to relieve the pruritus of canine AD. Somestudies indicate that synergistic effects could occur with concurrent use of essential fatty acid supplements. Consequently, at the time of this writing, there is insufficient evidence to conclude for or against the efficacyof antihistamines for treatment of canine AD. Additional blinded, randomized and controlled trials with larger numbers of patients are necessary to establish which of the antihistamine drugs currently available, if any, are truly efficacious for canine AD. Nevertheless, present clinician consensus suggests that several different antihistamine drugs should be evaluated in sequence, for 7-14 days each, in canine patients with AD. (C) 2001 ElsevierScience B.V. All rights reserved.

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Documento generato il 03/06/20 alle ore 00:01:28