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Titolo:
Biotransformation of organophosphorus compounds
Autore:
Jokanovic, M;
Indirizzi:
Univ Belgrade, Fac Pharm, Dept Toxicol, YU-11000 Belgrade, Yugoslavia UnivBelgrade Belgrade Yugoslavia YU-11000 YU-11000 Belgrade, Yugoslavia
Titolo Testata:
TOXICOLOGY
fascicolo: 3, volume: 166, anno: 2001,
pagine: 139 - 160
SICI:
0300-483X(20010925)166:3<139:BOOC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM PARAOXONASE; LIVER CYTOCHROME-P-450; TOXIC METABOLITES; A-ESTERASES; RAT-LIVER; SOMAN; MICE; GLUTATHIONE; PARATHION; INACTIVATION;
Keywords:
organophosphorus compounds; cytochrome P450; flavin-containing monooxygenases; phosphoric triester hydrolases; carboxylesterases; glutathione; biotransformation; detoxication;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
92
Recensione:
Indirizzi per estratti:
Indirizzo: Jokanovic, M Univ Belgrade, Fac Pharm, Dept Toxicol, Vojvode Stepe 450, YU-11000 Belgrade, Yugoslavia Univ Belgrade Vojvode Stepe 450 Belgrade Yugoslavia YU-11000
Citazione:
M. Jokanovic, "Biotransformation of organophosphorus compounds", TOXICOLOGY, 166(3), 2001, pp. 139-160

Abstract

This study reviews current understanding of mechanisms of biotransformation of organophosphorus compounds (OPC). The first part of this article covers chemical aspects of bio trans formation describing reactions that lead toactivation or detoxication of OPC. The second part explains biochemical mechanisms of biotransformation describing the role of enzymes that are involved in this process. Among them are the enzymes that take part in metabolicactivation of OPC such as cytochrome P450 system, NADPH-cytochrome P450 reductase and flavin-containing monooxygenases. Among enzymes participating in detoxication of OPC, the role of phosphoric triester hydrolases, carboxylesterases and glutathione redox system is explained. This article also deals with other aspects of detoxication of OPC such as protein binding and therole of tissue depots for these compounds. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:03:44