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Titolo:
Regional lidocaine infusion reduces postischemic spinal cord injury in rabbits
Autore:
Apaydin, AZ; Buket, S;
Indirizzi:
Ege Univ, Med Fac Hosp, Dept Cardiovasc Surg, TR-35100 Izmir, Turkey Ege Univ Izmir Turkey TR-35100 t Cardiovasc Surg, TR-35100 Izmir, Turkey
Titolo Testata:
TEXAS HEART INSTITUTE JOURNAL
fascicolo: 3, volume: 28, anno: 2001,
pagine: 172 - 176
SICI:
0730-2347(2001)28:3<172:RLIRPS>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRATHECAL TETRACAINE; THORACOABDOMINAL AORTA; ANEURYSM REPAIR; FLUID DRAINAGE; ISCHEMIA; HYPOTHERMIA; PARAPLEGIA; PROTECTION; PREVENTION; ADENOSINE;
Keywords:
animal; aorta, abdominal/surgery; ischemia/prevention & control; lidocaine/therapeutic use; paraplegia/prevention & control; spinal cord injuries/prevention & control; vascular surgical procedures/adverse effects;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Apaydin, AZ Ege Univ, Med Fac Hosp, Dept Cardiovasc Surg, TR-35100 Izmir, Turkey Ege Univ Izmir Turkey TR-35100 Surg, TR-35100 Izmir, Turkey
Citazione:
A.Z. Apaydin e S. Buket, "Regional lidocaine infusion reduces postischemic spinal cord injury in rabbits", TEX HEART I, 28(3), 2001, pp. 172-176

Abstract

Paraplegia secondary to spinal cord ischemia is a devastating complicationin operations on the descending and thoracoabdominal aorta. We hypothesized that the tolerance of the spinal cord to an ischemic insult could be improved by means of regional administration of lidocaine. Thirty-one New Zealand white rabbits were anesthetized and spinal cord ischemia was induced by the placement of clamps both below the left renal vein and above the aorticbifurcation. The animals were divided into 5 groups. Aortic occlusion timewas 20 minutes in Group 1 and 30 minutes in all other groups. Groups 1 and2 functioned as controls. Lidocaine (Group 5) or normal saline solution (Group 3) was infused into the isolated aortic segment after cross-clamping. Group 4 animals received 20% mannitol regionally, before and after reperfusion. Postoperatively. rabbits were classified as either neurologically normal or injured (paralyzed or paretic). Among controls, 20 minutes of aortic occlusion did not produce any neurologic deficit (Group 1: 0/4 injured), while 30 minutes of occlusion resulted in more consistent injury (Group 2: 6/8 injured). Animals that received normal saline (Group 3) or mannitol (Group 4) regionally showed 80% neurologic injury (4/5), Animals treated with the regional lidocaine infusion (Group 5) showed much better neurologic outcomes (7/9 normal: 78%). This superiority of Group 5 over Groups 2, 3, and 4 was significant (P <0.02). We conclude that regional administration of lidocaine reduced neurologic injury secondary to spinal cord ischemia and reperfusion after aortic occlusion in the rabbit model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 07:15:59