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Titolo:
Transplacental exposure to methylene blue initiates teratogenesis in the mouse: Preliminary evidence for a mechanistic implication of cyclic GMP pathway disruption
Autore:
Tiboni, GM; Lamonaca, D;
Indirizzi:
Univ G DAnnunzio, Osped Clinicizzato SS Annunziata, Dipartimento Med & SciInvecchiamento, Sez Ostetr & Ginecol,Fac Med & Chirurg, I-66013 Chieti, Italy Univ G DAnnunzio Chieti Italy I-66013 d & Chirurg, I-66013 Chieti, Italy
Titolo Testata:
TERATOLOGY
fascicolo: 4, volume: 64, anno: 2001,
pagine: 213 - 220
SICI:
0040-3709(200110)64:4<213:TETMBI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; GUANYLATE-CYCLASE; SUPEROXIDE ANION; SODIUM-NITROPRUSSIDE; JEJUNAL ATRESIA; RELAXING FACTOR; PROTEIN-KINASE; SEPTIC SHOCK; INHIBITION; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Tiboni, GM Univ G DAnnunzio, Osped Clinicizzato SS Annunziata, Dipartimento Med & SciInvecchiamento, Sez Ostetr & Ginecol,Fac Med & Chirurg, Via Vestini, I-66013 Chieti, Italy Univ G DAnnunzio Via Vestini Chieti Italy I-66013 hieti, Italy
Citazione:
G.M. Tiboni e D. Lamonaca, "Transplacental exposure to methylene blue initiates teratogenesis in the mouse: Preliminary evidence for a mechanistic implication of cyclic GMP pathway disruption", TERATOLOGY, 64(4), 2001, pp. 213-220

Abstract

Background: The vital dye methylene blue (MB) has been shown to be teratogenic when injected into the amnion in the second trimester. On the other hand, the teratogenic potential of transplacental exposure to MB has not beendetermined. Methods: MB was administered subcutaneously to ICR (CD-1) mice at 0, 35, 50, 60, or 70 mg/kg on gestation day 8 (plug day = day 0). Teratological assessments were carried out at term gestation, on gestation day 18. Since MB inhibits soluble guanylate cyclase enzyme activity, zaprinast (ZPN), a selective cGMP-phosphodiesterase type V inhibitor, was administered to prevent developmental disorders initiated by MB at 50 mg/kg. Results: There was a dose-dependent increment of embryolethality. MB treatment also produced axial skeleton and neural tube defects. Coadministrationof ZPN (20 mg/kg per three times) abolished completely MB-induced neural tube defects and reduced by one-half the incidence of fetuses exhibiting axial skeletal defects. ZPN did not provide protection against the embryocidaleffects of MB. Conclusions: This study showed that transplacental exposure to MB is teratogenic in the mouse. Coadministration of ZPN prevented partly MB-induced teratogenesis, which supports the hypothesis that imbalance of cGMP pathway accounts, in part, for the teratogenicity of MB. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:03:01