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Titolo:
The importance of cytochrome P450 monooxygenase CYP2D6 in palliative medicine
Autore:
Davis, MP; Homsi, J;
Indirizzi:
Cleveland Clin Fdn, Harry R Horvitz Ctr Palliat Med, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 at Med, Cleveland, OH 44195 USA
Titolo Testata:
SUPPORTIVE CARE IN CANCER
fascicolo: 6, volume: 9, anno: 2001,
pagine: 442 - 451
SICI:
0941-4355(200109)9:6<442:TIOCPM>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
STATE PLASMA-LEVELS; SEROTONIN REUPTAKE INHIBITORS; DRUG-METABOLIZING-ENZYMES; IN-VITRO; GENETIC-POLYMORPHISM; JAPANESE POPULATION; PROPAFENONE ENANTIOMERS; OXIDATIVE-METABOLISM; POOR METABOLIZERS; SERUM LEVELS;
Keywords:
CYP2D6; palliative medicine; drug metabolism; drug interactions; ethnic differences; pharmacokinetics;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
105
Recensione:
Indirizzi per estratti:
Indirizzo: Davis, MP Cleveland Clin Fdn, Harry R Horvitz Ctr Palliat Med, 9500 EuclidAve, Cleveland, OH 44195 USA Cleveland Clin Fdn 9500 Euclid Ave Cleveland OH USA 44195 95 USA
Citazione:
M.P. Davis e J. Homsi, "The importance of cytochrome P450 monooxygenase CYP2D6 in palliative medicine", SUPP CARE C, 9(6), 2001, pp. 442-451

Abstract

The enzymes in the cytochrome p450 monooxygenase system (CYP) are the major enzymes responsible for metabolizing medications. The CYP2D6 isomer is responsible for metabolizing certain opioids, neuroleptics, antidepressants and cardiac medications. Owing to CYP2D6's low capacity and high affinity itis easily saturated by substrate and/or inhibited, resulting in pharmacokinetic interactions. Polymorphisms of the structural gene are common, leading to wide inter-individual and ethnic differences in drug metabolism. Clinically important drug interactions, which may be anticipated in the palliative medicine population, are reviewed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:14:11