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Titolo:
Studies of brain and cognitive maturation through childhood and adolescence: A strategy for testing neurodevelopmental hypotheses
Autore:
Luna, B; Sweeney, JA;
Indirizzi:
Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, Neurobehav StudiesProgram, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 Program, Pittsburgh, PA 15213 USA Univ Chicago, Sch Med, Neurocognit Assessment & Brain Imaging Program, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 Imaging Program, Chicago, IL 60637 USA
Titolo Testata:
SCHIZOPHRENIA BULLETIN
fascicolo: 3, volume: 27, anno: 2001,
pagine: 443 - 455
SICI:
0586-7614(2001)27:3<443:SOBACM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSOLATERAL PREFRONTAL CORTEX; SPATIAL WORKING-MEMORY; CARD SORTING TEST; SACCADIC EYE-MOVEMENTS; FUNCTIONAL MAGNETIC-RESONANCE; POSITRON EMISSION TOMOGRAPHY; JERUSALEM INFANT DEVELOPMENT; SCHIZOPHRENIC-PATIENTS; NEUROPSYCHOLOGICAL EVIDENCE; NEUROBEHAVIORAL DEFICITS;
Keywords:
spatial working memory; inhibition; eye movements; cerebellum; neuroimaging; prefrontal cortex;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
110
Recensione:
Indirizzi per estratti:
Indirizzo: Luna, B Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, NeurobehavStudiesProgram, 3501 Forbes Ave,Oxford Bldg,Room 743, Pittsburgh, PA 15213USA Univ Pittsburgh 3501 Forbes Ave,Oxford Bldg,Room 743 Pittsburgh PA USA15213
Citazione:
B. Luna e J.A. Sweeney, "Studies of brain and cognitive maturation through childhood and adolescence: A strategy for testing neurodevelopmental hypotheses", SCHIZO BULL, 27(3), 2001, pp. 443-455

Abstract

Although neurodevelopmental models of schizophrenia are now widely accepted, there is minimal direct human evidence of dysmaturation in schizophreniato support this theory. This is especially the case regarding maturationalchanges during late childhood and adolescence, which immediately precede the typical age of onset of the disorder. By integrating new noninvasive methods of functional magnetic resonance imaging with techniques of developmental cognitive neuroscience, It is now possible to begin systematic researchprograms to directly test hypotheses of neurodevelopmental abnormalities in schizophrenia. In this article, we describe strategies for characterizingdevelopmental changes taking place during the critical period of adolescence that can elucidate dysmaturation processes in schizophrenia. We emphasize the need for studies characterizing normal development before examining at-risk or clinical populations, and the potential value of using neurobehavioral and neuroimaging approaches to directly characterize the dysmaturation associated with schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/12/19 alle ore 11:49:29