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Titolo:
Regionally diverse cortical pathology in schizophrenia: Clues to the etiology of the disease
Autore:
Selemon, LD;
Indirizzi:
Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT 06520 USA Yale Univ NewHaven CT USA 06520 Dept Neurobiol, New Haven, CT 06520 USA
Titolo Testata:
SCHIZOPHRENIA BULLETIN
fascicolo: 3, volume: 27, anno: 2001,
pagine: 349 - 377
SICI:
0586-7614(2001)27:3<349:RDCPIS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; LOCAL CIRCUIT NEURONS; POSITRON-EMISSION-TOMOGRAPHY; PLANUM TEMPORALE ASYMMETRY; ANTERIOR CINGULATE CORTEX; PRIMATE PREFRONTAL CORTEX; MESSENGER-RNA EXPRESSION; DENDRITIC SPINE DENSITY; HOMO-SAPIENS PAYS; SYNAPTIC PATHOLOGY;
Keywords:
postmortem; stereologic; thalamus; prefrontal; human;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
165
Recensione:
Indirizzi per estratti:
Indirizzo: Selemon, LD Yale Univ, Sch Med, Dept Neurobiol, POB 208001, New Haven, CT 06520 USA Yale Univ POB 208001 New Haven CT USA 06520 aven, CT 06520 USA
Citazione:
L.D. Selemon, "Regionally diverse cortical pathology in schizophrenia: Clues to the etiology of the disease", SCHIZO BULL, 27(3), 2001, pp. 349-377

Abstract

Perhaps the most surprising revelation that has emerged from recent pathologic studies of schizophrenia is the marked cortical regional heterogeneityof the disease. Areal specific alterations of many parameters have been reported (e.g., neuronal density, density of gamma -aminobutyric acid [GABA]-immunoreactive cells, and concentration of synapse-associated proteins and messenger ribonucleic acid [mRNA]s). In the past 5 years, as a flood of seemingly contradictory findings have been published, divergent findings oftenhave been regarded as further evidence of the irreplicability and futilityof postmortem studies. Although some discrepancies In findings may be due to methodological differences or to the study of different cohorts of patients, a growing number of laboratories are examining the same parameter(s) in multiple cortical areas in a single brain cohort and finding regionally specific abnormalities. These findings provide compelling evidence that cortical pathology in schizophrenia is nonuniform and complex. A major challenge in contemporary schizophrenia research is to make sense of the patterningof whole brain pathology in schizophrenia, as the mosaic of neuropathologic alterations may provide clues to the disease etiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 14:38:50