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Titolo:
Early brain wiring: Activity-dependent processes
Autore:
Penn, AA;
Titolo Testata:
SCHIZOPHRENIA BULLETIN
fascicolo: 3, volume: 27, anno: 2001,
pagine: 337 - 347
SICI:
0586-7614(2001)27:3<337:EBWAP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
OCULAR DOMINANCE COLUMNS; LONG-TERM POTENTIATION; SPONTANEOUS RETINAL ACTIVITY; CAT VISUAL-CORTEX; SYNAPTIC PLASTICITY; SUBPLATE NEURONS; STRIATE CORTEX; GANGLION-CELLS; SCHIZOPHRENIC-PATIENTS; INTERSTITIAL NEURONS;
Keywords:
neural activity; cortical development; neuronal connectivity; activity-dependent processes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
81
Recensione:
Indirizzi per estratti:
Citazione:
A.A. Penn, "Early brain wiring: Activity-dependent processes", SCHIZO BULL, 27(3), 2001, pp. 337-347

Abstract

One of the leading theories of the neuropathology of schizophrenia is thatit is a developmental disorder of "neural connectivity. " To assess this theory, it is first necessary to understand how precise neural connections normally are established. Sensory-driven neural activity has been widely recognized as crucial for this process. Recent studies have revealed a similar requirement for endogenous neural activity generated by the nervous system itself, long before there is any sensory input. These patterns of sensory-driven and endogenously generated neural activity sculpt the precise circuits that are crucial to the many complex functions of the adult brain. This article summarizes the principles of activity-dependent neural development as determined from basic neuroscience experiments, particularly those done using the mammalian visual system, to illustrate the role of patterned activity, neuronal competition, and critical periods in shaping neural circuitry. The potential molecular mechanisms involved in these features of activity-dependent neurodevelopment are discussed and possible links to the etiology of schizophrenia are briefly explored.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/11/19 alle ore 02:59:49