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Titolo:
The formalin test: Effects of formalin concentration and short-term halothane inhalation
Autore:
Fukuda, T; Nishimoto, C; Shiga, Y; Toyooka, H;
Indirizzi:
Univ Tsukuba, Dept Anesthesiol, Inst Clin Med, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan
Titolo Testata:
REGIONAL ANESTHESIA AND PAIN MEDICINE
fascicolo: 5, volume: 26, anno: 2001,
pagine: 407 - 413
SICI:
1098-7339(200109/10)26:5<407:TFTEOF>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-FOS EXPRESSION; RAT SPINAL-CORD; DORSAL HORN; STIMULATION; PAIN; PROTEIN; NOCICEPTION; LIDOCAINE; MORPHINE; NEURONS;
Keywords:
formalin test; behavioral pain rating; c-fos; halothane;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Fukuda, T Univ Tsukuba, Dept Anesthesiol, Inst Clin Med, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 araki 3058575, Japan
Citazione:
T. Fukuda et al., "The formalin test: Effects of formalin concentration and short-term halothane inhalation", REG ANES PA, 26(5), 2001, pp. 407-413

Abstract

Background and objectives: In order to evaluate the effects of formalin concentration and inhalational anesthetics in formalin tests, we injected 5 concentrations of formalin into awake and anesthetized rats and investigatedtheir behavior and the c-fos immunoreactivity of their spinal cords. Methods: Sixty adult male Sprague-Dawley rats were divided into 10 experimental groups. Each rat was either manually restrained or subdued through several minutes of 2% to 2.5% halothane inhalation, and then 1 of 5 concentrations of 0%, 5%, 10%,27%, or 100% formalin (0%, 1.85%,3.7%, 10%, or 37% formaldehyde solutions) was injected into its rear paw. Nociceptive behaviors were checked for 1 hour, 6 times for each 5 -minute period. Two hours afterthe formalin injections, the rats were killed and c-fos immunoreactivity was measured. Results: Typical responses were observed in the 5% and 10% formalin (1.85%and 3.7% formaldehyde) groups, and nociceptive behaviors were lower in the27% and 100% formalin (10% and 37% formaldehyde) groups. The number of c-fos-positive cells increased as the formalin concentration increased. Halothane inhalation affected the results of both the behavior and the c-fos immunoreactivity, especially in the 10% formalin (3.7% formaldehyde) group. Conclusions: It is desirable to describe both formalin and formaldehyde concentrations simultaneously and to do formalin tests without inhalational anesthetics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 11:25:15