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Titolo:
A double-blind placebo-controlled crossover study of phenytoin in individuals with impulsive aggression
Autore:
Stanford, MS; Houston, RJ; Mathias, CW; Greve, KW; Villemarette-Pittman, NR; Adams, D;
Indirizzi:
Univ New Orleans, Dept Psychol, New Orleans, LA 70148 USA Univ New Orleans New Orleans LA USA 70148 chol, New Orleans, LA 70148 USA Univ Texas, Hlth Sci Ctr, Dept Psychiat & Behav Sci, Houston, TX USA Univ Texas Houston TX USA tr, Dept Psychiat & Behav Sci, Houston, TX USA Jefferson Neurol Associates, Metairie, LA USA Jefferson Neurol AssociatesMetairie LA USA Associates, Metairie, LA USA
Titolo Testata:
PSYCHIATRY RESEARCH
fascicolo: 2-3, volume: 103, anno: 2001,
pagine: 193 - 203
SICI:
0165-1781(20010920)103:2-3<193:ADPCSO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREMEDITATED AGGRESSION; POTENTIALS;
Keywords:
aggression; phenytoin; evoked potentials; P1; N1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Stanford, MS Univ New Orleans, Dept Psychol, 2001 Geol & Psychol Bldg, NewOrleans, LA 70148 USA Univ New Orleans 2001 Geol & Psychol Bldg New Orleans LA USA 70148
Citazione:
M.S. Stanford et al., "A double-blind placebo-controlled crossover study of phenytoin in individuals with impulsive aggression", PSYCHIAT R, 103(2-3), 2001, pp. 193-203

Abstract

The present study examines the behavioral and psychophysiological effects of phenytoin (PHT) in individuals who display impulsive -aggressive outbursts. In a double-blind placebo-controlled crossover design, individuals meeting previously established criteria for impulsive aggression were administered PHT and placebo during separate 6-week conditions. The efficacy measures used were the Overt Aggression Scale (OAS) and the Profile of Mood States(POMS). Psychophysiological measures (evoked potentials) were taken at baseline and at the end of each 6-week condition. Photic stimulation was used to evoke the mid-latency P1-N1-P2 waveform complex. Analysis indicated a significant decrease in the frequency of im pul sive -aggressive outbursts during PHT administration compared to baseline and placebo. Analysis of the psychophysiological data showed significantly increased PI amplitude and significantly longer N1 latency during PHT administration. In addition, a reduction in N1 amplitude during PHT administration was also suggested. These findings indicate reparation of physiological abnormalities previously observed in impulsive- aggressive individuals and imply more efficient sensory processing and effective orienting of attention. Taken together, these results provide insight as to the physiological mechanisms by which PHT serves to ameliorate impulsive-aggressive behavior. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 31/03/20 alle ore 16:27:44