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Titolo:
Linked polymorphisms (-333G > T and -286A > G) in the promoter region of the CCK-A receptor gene may be associated with schizophrenia
Autore:
Tachikawa, H; Harada, S; Kawanishi, Y; Okubo, T; Suzuki, T;
Indirizzi:
Univ Tsukuba, Inst Clin Med, Dept Psychiat, Tsukuba, Ibaraki 3050003, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3050003 sukuba, Ibaraki 3050003, Japan Univ Tsukuba, Inst Community Med, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan Kurita Hosp, Dept Psychiat, Ibaraki, Osaka 3110117, Japan Kurita Hosp Ibaraki Osaka Japan 3110117 at, Ibaraki, Osaka 3110117, Japan
Titolo Testata:
PSYCHIATRY RESEARCH
fascicolo: 2-3, volume: 103, anno: 2001,
pagine: 147 - 155
SICI:
0165-1781(20010920)103:2-3<147:LP(>TA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLECYSTOKININ GENE; DOPAMINE; EXPRESSION; RELEASE; RECOMMENDATIONS; ALCOHOLISM; METABOLISM; UPSTREAM; DISORDER; MUTATION;
Keywords:
cholecystokinin A receptor; association analysis; auditory hallucination; paranoid subtype;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Tachikawa, H Univ Tsukuba, Inst Clin Med, Dept Psychiat, 2-21-14 Sakura, Tsukuba, Ibaraki 3050003, Japan Univ Tsukuba 2-21-14 Sakura Tsukuba Ibaraki Japan 3050003 pan
Citazione:
H. Tachikawa et al., "Linked polymorphisms (-333G > T and -286A > G) in the promoter region of the CCK-A receptor gene may be associated with schizophrenia", PSYCHIAT R, 103(2-3), 2001, pp. 147-155

Abstract

Cholecystokinin A receptors (CCKAR) modulate CCK-stimulated dopamine release, and mutations in the CCKAR gene may predispose affected individuals to schizophrenia. Our previous study suggested that -286A > G polymorphism (previously named 201 A > G) in the CCKAR gene promoter is associated with schizophrenia. In the present study, we carried out a further investigation ofthe promoter and intron I of the CCKAR gene. In addition to polyrnorphismsreported previously (-333G > T, -286A > G, -241G > A, 773A > T, and 779T >C), two novel polymorphisms (-388(GT)(8) > (GT)(9) and -85C > G) were identified. These polymorphisms were in a linkage disequilibrium. Association analyses between schizophrenic patients and controls revealed that the frequencies of the A allele and AA genotype at the -286 loci, as well as the frequency of the GG genotype at the -333 loci, were significantly higher in patients than in controls. Furthermore, patients with paranoid type schizophrenia, auditory hallucinations, or a positive family history had a significantly higher frequency of the -286A allele than the control group. The results supported our previous data, and suggest the possible involvement of the-333G > T and the -286A > G polymorphisms in the promoter region of the CCKAR gene in the predisposition to schizophrenia. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:38:37