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Titolo:
Decreased platelet [H-3]paroxetine binding sites in suicide attempters
Autore:
Marazziti, D; DellOsso, L; Rossi, A; Masala, I; Baroni, S; Armani, A; Giannaccini, G; Di Nasso, E; Lucacchini, A; Cassano, GB;
Indirizzi:
Univ Pisa, Dipartimento Psichiat Neurobiol Farmacol & Biotec, I-56100 Pisa, Italy Univ Pisa Pisa Italy I-56100 biol Farmacol & Biotec, I-56100 Pisa, Italy
Titolo Testata:
PSYCHIATRY RESEARCH
fascicolo: 2-3, volume: 103, anno: 2001,
pagine: 125 - 131
SICI:
0165-1781(20010920)103:2-3<125:DP[BSI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 PAROXETINE BINDING; SEROTONIN TRANSPORTER GENE; IMIPRAMINE-BINDING; CEREBROSPINAL-FLUID; HIGH-AFFINITY; 5-HYDROXYTRYPTAMINE UPTAKE; IMPULSIVE AGGRESSION; PERSONALITY-DISORDER; BRAIN; BEHAVIOR;
Keywords:
suicide; serotonin; platelets; serotonin transporter; [H-3]paroxetine binding;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Marazziti, D Univ Pisa, Dipartimento Psichiat Neurobiol Farmacol & Biotec,Via Roma 67,I-56100 Pisa, Italy Univ Pisa Via Roma 67 Pisa Italy I-56100 I-56100 Pisa, Italy
Citazione:
D. Marazziti et al., "Decreased platelet [H-3]paroxetine binding sites in suicide attempters", PSYCHIAT R, 103(2-3), 2001, pp. 125-131

Abstract

Research to date would suggest the possible involvement of the serotonin (5-HT) system in the pathophysiology of suicide. With this study, we aimed to investigate the platelet 5-HT transporter, by means of the specific binding of tritiated paroxetine ([H-3]Par), in a sample of 20 suicide attemptersrecruited at a first-aid service, as compared with healthy control subjects and psychiatric patients with no current or previous history of suicide attempt. The results, showing a decreased number of [H-3]Par binding sites in suicide attempters, would suggest the involvement of the presynaptic 5-HTtransporter in self-aggressive behavior. (C) 2001 Elsevier Science IrelandLtd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:14:14