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Titolo:
Retrograde signaling at central synapses
Autore:
Tao, HZW; Poo, MM;
Indirizzi:
Univ Calif Berkeley, Dept Mol & Cellular Biol, Berkeley, CA 94720 USA UnivCalif Berkeley Berkeley CA USA 94720 ar Biol, Berkeley, CA 94720 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 20, volume: 98, anno: 2001,
pagine: 11009 - 11015
SICI:
0027-8424(20010925)98:20<11009:RSACS>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; DEPOLARIZATION-INDUCED SUPPRESSION; CELL-ADHESION MOLECULES; NERVE GROWTH-FACTOR; DEVELOPING NEUROMUSCULAR SYNAPSES; INDUCED SYNAPTIC POTENTIATION; CULTURED HIPPOCAMPAL-NEURONS; NMDA RECEPTOR ACTIVATION; BDNF KNOCKOUT MICE; RAT VISUAL-CORTEX;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
146
Recensione:
Indirizzi per estratti:
Indirizzo: Poo, MM Univ Calif Berkeley, Dept Mol & Cellular Biol, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 Berkeley, CA 94720 USA
Citazione:
H.Z.W. Tao e M.M. Poo, "Retrograde signaling at central synapses", P NAS US, 98(20), 2001, pp. 11009-11015

Abstract

Transcellular retrograde signaling from the postsynaptic target cell to the presynaptic neuron plays critical roles in the formation, maturation, andplasticity of synaptic connections. We here review recent progress in our understanding of the retrograde signaling at developing central synapses. Three forms of potential retrograde signals-membrane-permeant factors, membrane-bound factors, and secreted factors-have been implicated at both developing and mature synapses. Although many of these signals may be active constitutively, retrograde factors produced in association with activity-dependent synaptic plasticity, e.g., long-term potentiation and long-term depression, are of particular interest, because they may induce modification of neuronal excitability and synaptic transmission, functions directly related to the processing and storage of information in the nervous system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 10:00:34