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Titolo:
Screening for trisomy 21 in twin pregnancies in the first trimester: does chorionicity impact on maternal serum free beta-hCG or PAPP-A levels?
Autore:
Spencer, K;
Indirizzi:
Harold Wood Hosp, Endocrine Unit, Dept Clin Biochem, Romford RM3 0BE, Essex, England Harold Wood Hosp Romford Essex England RM3 0BE rd RM3 0BE, Essex, England
Titolo Testata:
PRENATAL DIAGNOSIS
fascicolo: 9, volume: 21, anno: 2001,
pagine: 715 - 717
SICI:
0197-3851(200109)21:9<715:SFT2IT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
FETAL NUCHAL TRANSLUCENCY; THICKNESS;
Keywords:
NT; PAPP-A; free beta-hCG; prenatal screening; first trimester; twins; Down syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Spencer, K Harold Wood Hosp, Endocrine Unit, Dept Clin Biochem, Gubbins Lane, RomfordRM3 0BE, Essex, England Harold Wood Hosp Gubbins Lane Romford Essex England RM3 0BE and
Citazione:
K. Spencer, "Screening for trisomy 21 in twin pregnancies in the first trimester: does chorionicity impact on maternal serum free beta-hCG or PAPP-A levels?", PRENAT DIAG, 21(9), 2001, pp. 715-717

Abstract

In a study of 180 twin pregnancies I have examined the distribution of maternal serum free beta -human chorionic gonadotrophin (beta -hCG) and pregnancy-associated plasma protein-A (PAPP-A), in addition to fetal nuchal translucency thickness (NT), in twins classified as monochorionic or dichorionic, based on ultrasound appearance at 10-14 weeks of gestation. In 45 monochorionic and 135 dichorionic twin pregnancies the median MoM free beta -hCG was not significantly different (1.00 vs 1.01), whilst that for PAPP-A was lower (0.89 vs 1.01) but again with no statistical significance. Previous reports of an increased fetal NT in monochorionic twins pregnancies could notbe confirmed (1.03 vs 1.00). It is concluded that the existing pseudo risktwin correction algorithm is appropriate for both monochorionic and dichorionic twins in providing accurate first trimester risks for trisomy 21. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 18:17:34