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Titolo:
Preimplantation genetic diagnosis of pericentric inversions
Autore:
Escudero, T; Lee, M; Stevens, J; Sandalinas, M; Munne, S;
Indirizzi:
St Barnabas Hosp, Inst Reprod Med & Sci, Livingston, NJ 07052 USA St Barnabas Hosp Livingston NJ USA 07052 & Sci, Livingston, NJ 07052 USA New England Clin Reprod Med Inc, Reading, MA 01867 USA New England Clin Reprod Med Inc Reading MA USA 01867 eading, MA 01867 USA Colorado Ctr Reprod Med, Englewood, CO 80110 USA Colorado Ctr Reprod Med Englewood CO USA 80110 d, Englewood, CO 80110 USA
Titolo Testata:
PRENATAL DIAGNOSIS
fascicolo: 9, volume: 21, anno: 2001,
pagine: 760 - 766
SICI:
0197-3851(200109)21:9<760:PGDOPI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
WOLF-HIRSCHHORN-SYNDROME; RECIPROCAL TRANSLOCATION; PRECONCEPTION DIAGNOSIS; INTERPHASE CELLS; PROBES; CHROMOSOME-4; COUPLES; EMBRYOS; PATIENT;
Keywords:
PGD; inv(2); inv(4); translocation; u-recombination;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Munne, S St Barnabas Hosp, 101 Old Shorts Hills,Suite 501, Orange, NJ 07052 USA St Barnabas Hosp 101 Old Shorts Hills,Suite 501 Orange NJ USA 07052
Citazione:
T. Escudero et al., "Preimplantation genetic diagnosis of pericentric inversions", PRENAT DIAG, 21(9), 2001, pp. 760-766

Abstract

Inversions are structural chromosome abnormalities that may be associated with infertility, multiple miscarriage and chromosomally unbalanced offspring. Preimplantation genetic diagnosis (PGD) with subtelomeric probes was used to select for transfer only those embryos that were normal or balanced for three pericentric inversions. In contrast to previous protocols the present procedure allows the detection of unbalanced embryos that might arise from U-recombination in the inverted region. Additionally, aneuploidy screening was carried out in two cases by a second round of fluorescent in situ hybridization (FISH) with centromeric probes. Of the three couples that underwent the procedure one became pregnant twice. The first pregnancy delivered a healthy and chromosomally normal baby and the second pregnancy is ongoing with triplets. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:17:59