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Titolo:
Antiradical and antilipoperoxidative effects of some plant extracts used by sri lankan traditional medical practitioners for cardioprotection
Autore:
Chaminda, T; Munasinghe, J; Seneviratne, CK; Thabrew, MI; Abeysekera, AM;
Indirizzi:
Univ Sri Jayewardenepura, Fac Med Sci, Dept Biochem, Nugegoda, Sri Lanka Univ Sri Jayewardenepura Nugegoda Sri Lanka iochem, Nugegoda, Sri Lanka Univ Kelaniya, Fac Med, Dept Biochem & Clin Chem, Ragama, Sri Lanka Univ Kelaniya Ragama Sri Lanka t Biochem & Clin Chem, Ragama, Sri Lanka Univ Sri Jayewardenepura, Fac Sci Appl, Dept Chem, Nugegoda, Sri Lanka Univ Sri Jayewardenepura Nugegoda Sri Lanka t Chem, Nugegoda, Sri Lanka
Titolo Testata:
PHYTOTHERAPY RESEARCH
fascicolo: 6, volume: 15, anno: 2001,
pagine: 519 - 523
SICI:
0951-418X(200109)15:6<519:AAAEOS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-FAILURE SUBSEQUENT; MYOCARDIAL-INFARCTION; TERMINALIA-ARJUNA; ANTIOXIDANT; RADICALS; DRUGS; ACID;
Keywords:
reactive oxygen species; cardiovascular system; antioxidants; Ayurvedic; 1,1-diphenyl-2-picrylhydrazyl; free radical; deoxyribose; Wistar rats; lipid peroxidation; pro-oxidant activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Seneviratne, CK Univ Sri Jayewardenepura, Fac Med Sci, Dept Biochem, Nugegoda, Sri Lanka Univ Sri Jayewardenepura Nugegoda Sri Lanka , Sri Lanka
Citazione:
T. Chaminda et al., "Antiradical and antilipoperoxidative effects of some plant extracts used by sri lankan traditional medical practitioners for cardioprotection", PHYTOTHER R, 15(6), 2001, pp. 519-523

Abstract

Reactive oxygen species (ROS) are implicated in many pathogenic processes including the cardiovascular system. Detoxification of ROS by antioxidants (AO) therefore affords protection against such diseases. There is a growingbody of evidence suggesting that antioxidants contribute to cardioprotection. Therefore, nine plants that are components of Ayurvedic formulations used for the therapy of cardiovascular diseases were investigated to determine whether antioxidant activity is one of the mechanisms by which these plants exert cardioprotection. Initially aqueous freeze dried extracts of the plants were prepared and the antioxidant activity was measured (a) in vitro, by DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging and deoxyribose damage protection assays,and (b) in vivo, by effects on lipid peroxidation. Terminalia arjuna showed significant DPPH radical scavenging activity with EC50 8.3 +/- 0.3 mug/mL(similar to L-ascorbic acid). The potency of this activity was much lower in Cassia fistula (EC50 = 59.0 +/- 2.7 mug/mL). The other seven extracts demonstrated no such activity in the concentration range tested. In the deoxyribose damage protection assay, T. arjuna demonstrated no significant effect in the concentration range 0-20 mug/mL, but above 20 mug/mL concentration(20-125 mug/ml), a pro-oxidant activity was observed (although markedly less than demonstrated by L-ascorbic acid). A similar trend was observed withVitex negundo. In contrast, C fistula afforded a 30% protection against such damage at 125 mug/ml, concentration. Other plant extracts did not show any activity in this assay. At a dose of 90 mg/kg (single dose) T. arjuna, cardiac lipid peroxidation in mate Wistar rats was reduced by 38.8% +/- 2.6%(p <0.05) whereas the reduction was only 11.6% +/- 3.5% in the case of C fistula even at a dose of 120 mg/kg. Of all the plants tested, T. arjuna demonstrated the highest antioxidant activity. Overall results show that only some plants used in the therapy of cardiovascular disease exert their beneficial effects via antioxidant activity. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:27:43