Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Azithromycin: An assessment of its pharmacokinetics and therapeutic potential in CAPD
Autore:
Kent, JR; Almond, MK; Dhillon, S;
Indirizzi:
Southend Hosp, Dept Pharm, Westcliff On Sea SS0 0RY, Essex, England Southend Hosp Westcliff On Sea Essex England SS0 0RY 0RY, Essex, England
Titolo Testata:
PERITONEAL DIALYSIS INTERNATIONAL
fascicolo: 4, volume: 21, anno: 2001,
pagine: 372 - 377
SICI:
0896-8608(200107/08)21:4<372:AAAOIP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
RHODOCOCCUS-EQUI; RENAL-FAILURE; SERUM; OTOTOXICITY; DISEASE; TISSUES; INVITRO; DRUGS;
Keywords:
azithromycin; peritonitis; pharmacokinetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Kent, JR Southend Hosp, Dept Pharm, Westcliff On Sea SS0 0RY, Essex, England Southend Hosp Westcliff On Sea Essex England SS0 0RY ex, England
Citazione:
J.R. Kent et al., "Azithromycin: An assessment of its pharmacokinetics and therapeutic potential in CAPD", PERIT DIA I, 21(4), 2001, pp. 372-377

Abstract

Background., Azithromycin is an azalide antibiotic with a similar antibacterial spectrum to erythromycin but with greater gram-negative activity. Azithromycin displays a favorable pharmacokinetic profile, with improved absorption and higher sustained tissue concentrations compared with erythromycin. This results in a prolonged elimination half-life, suggesting a potentialfor treating continuous ambulatory peritoneal dialysis (CAPD) peritonitis. Objective:This study aimed to define the potential role of azithromycin intreating CAPD peritonitis. Design:The pharmacokinetics and peritoneal dialysis (PD) clearance of azithromycin were studied following a single 500-mg oral dose of azithromycin. Blood and dialysate samples were taken over a 10-day period and assayed using high-pressure liquid chromatography. Setting: The study took place within the Renal Unit at Southend Hospital NHS Trust, a district general hospital in the United Kingdom. Patients: Eight patients with oliguric end-stage renal failure without peritonitis maintained on CAPD (3 x 2 L/day). *Results: Peak plasma concentrations occurred at 2 3 hours with 0.35 - 1.35mug/mL (mean 0.75). The mean elimination half-life was 84.55 hrs, and plasma clearance was 21.93 L/hour. This compares with values of greater than 40hours and 40.8 L/hour reported in healthy volunteers. After 8 hours, the mean dialysate concentration was 0.07 mug/mL; PD clearance was 0.06 L/hr. Conclusion: Azithromycin is not substantially removed by CAPD in the absence of peritonitis and cannot be recommended for widespread use in this setting at present. However, the successful use of azithromycin in CAPD peritonitis, due possibly to an intracellular drug transport mechanism, has been reported. Future research should address this possibility.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 14:09:33