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Titolo:
Future of neuroprotection in Parkinson's disease
Autore:
Naoi, M; Maruyama, W;
Indirizzi:
Inst Appl Biochem, Dept Brain Sci, Gifu, Japan Inst Appl Biochem Gifu Japan Appl Biochem, Dept Brain Sci, Gifu, Japan Natl Inst Lonev Sci, Dept Basic Gerontol, Obu, Japan Natl Inst Lonev Sci Obu Japan onev Sci, Dept Basic Gerontol, Obu, Japan
Titolo Testata:
PARKINSONISM & RELATED DISORDERS
fascicolo: 2, volume: 8, anno: 2001,
pagine: 139 - 145
SICI:
1353-8020(200110)8:2<139:FONIPD>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROBLASTOMA SH-SY5Y CELLS; DEPRENYL; APOPTOSIS; NEURONS; NEUROTOXICITY; RAT; N-METHYL-(R)-SALSOLINOL; INHIBITION; MPTP;
Keywords:
apoptosis; propargylamines; mitochondrial membrane potential; anti-apoptotic drugs; caspase 3; glyceraldehyde 3-phosphate dehydrogenase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Naoi, M Inst Appl Biochem, Dept Brain Sci, Gifu, Japan Inst Appl Biochem Gifu Japan ochem, Dept Brain Sci, Gifu, Japan
Citazione:
M. Naoi e W. Maruyama, "Future of neuroprotection in Parkinson's disease", PARKINS R D, 8(2), 2001, pp. 139-145

Abstract

In Parkinson's disease neuroprotective therapy to rescue dopamine neurons has been proposed. Selegiline is one of neuroprotective drug candidates, asproved by in vivo and in vitro experiments. In this paper, the mechanism underlying neuroprotection by selegiline and related propargylamines was studied against apoptosis induced by an endogenous toxin, N-methyl(R)salsolinol, synthetic 6-hydroxydopamine and peroxynitrite in dopaminergic SH-SY5Y cells. Propargylamines prevented apoptotic DNA damage, through suppression ofcollapse in mitochondrial membrane potential and following activation of caspase 3 and signal transduction to nuclei. These results suggest that propargylamines may rescue or protect dopamine neurons in Parkinson's disease. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/05/20 alle ore 10:55:46