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Titolo:
Dystonia and parkinsonism
Autore:
Jankovic, J; Tintner, R;
Indirizzi:
Baylor Coll Med, Dept Neurol, Parkinsons Dis Ctr, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 nsons Dis Ctr, Houston, TX 77030 USA Baylor Coll Med, Dept Neurol, Movement Disorders Clin, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 isorders Clin, Houston, TX 77030 USA
Titolo Testata:
PARKINSONISM & RELATED DISORDERS
fascicolo: 2, volume: 8, anno: 2001,
pagine: 109 - 121
SICI:
1353-8020(200110)8:2<109:DAP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; LEVODOPA-INDUCED DYSKINESIAS; DOPA-RESPONSIVE DYSTONIA; MACHADO-JOSEPH-DISEASE; HALLERVORDEN-SPATZ DISEASE; MULTIPLE SYSTEM ATROPHY; EARLY-MORNING DYSTONIA; ESSENTIAL TREMOR MAPS; DROPPED HEAD SYNDROME; HUNTINGTONS-DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
140
Recensione:
Indirizzi per estratti:
Indirizzo: Jankovic, J Baylor Coll Med, Dept Neurol, Parkinsons Dis Ctr, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 r, Houston, TX 77030 USA
Citazione:
J. Jankovic e R. Tintner, "Dystonia and parkinsonism", PARKINS R D, 8(2), 2001, pp. 109-121

Abstract

Parkinsonism and dystonia may coexist in a number of neurodegenerative, genetic, toxic, and metabolic disorders and as a result of structural lesionsin the basal ganglia. Parkinson's disease (PD) and the 'Parkinson-plus' syndromes (PPS) account for the majority of patients with the parkinsonism-dystonia combination. Dystonia, particularly when it involves the foot, may be the presenting sign of PD or PPS and these disorders should be suspected when adults present with isolated foot dystonia. Young age, female gender, and long disease duration are risk factors for PD-related dystonia, but dystonia in patients with PD is usually related to levodopa therapy. The mechanism of dystonia in PD is not well understood and the management is often challenging because levodopa and other dopaminergic agents may either improve or worsen dystonia. Other therapeutic strategies include oral medications(baclofen, anticholinergics and benzodiazepines), local injections of botulinum toxin, intrathecal baclofen, and surgical lesions or high frequency stimulation of the thalamus, globus pallidus, or subthalamus. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:15:03