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Titolo:
Molecular neurotoxicological models of Parkinsonism: focus on genetic manipulation of mice
Autore:
Cadet, JL;
Indirizzi:
NIDA, Intramural Res Program, Mol Neuropsychiat Sect, NIH, Baltimore, MD 21224 USA NIDA Baltimore MD USA 21224 ropsychiat Sect, NIH, Baltimore, MD 21224 USA
Titolo Testata:
PARKINSONISM & RELATED DISORDERS
fascicolo: 2, volume: 8, anno: 2001,
pagine: 85 - 90
SICI:
1353-8020(200110)8:2<85:MNMOPF>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISMUTASE TRANSGENIC MICE; METHAMPHETAMINE-INDUCED NEUROTOXICITY; NEURONAL NITRIC-OXIDE; CUZN-SUPEROXIDE DISMUTASE; DNA-DAMAGING AGENTS; WILD-TYPE P53; SUBSTANTIA-NIGRA; DOPAMINERGIC NEUROTOXICITY; STRIATAL DOPAMINE; OXIDATIVE STRESS;
Keywords:
Parkinson's disease; free radicals; knockout mice; transgenic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
101
Recensione:
Indirizzi per estratti:
Indirizzo: Cadet, JL NIDA, Intramural Res Program, Mol Neuropsychiat Sect, NIH, 5500 Nathan Shock Dr, Baltimore, MD 21224 USA NIDA 5500 Nathan Shock Dr Baltimore MD USA 21224 e, MD 21224 USA
Citazione:
J.L. Cadet, "Molecular neurotoxicological models of Parkinsonism: focus on genetic manipulation of mice", PARKINS R D, 8(2), 2001, pp. 85-90

Abstract

Parkinson's disease is a neurodegenerative disorder that affects mainly the nigrostriatal doparminergic system in humans. Several propositions have been put forward to explain the cellular and molecular pathobiology of this syndrome. Initial attempts were made through the use of various agents to manipulate the deleterious effects of toxins that destroy dopaminergic cellsboth in vitro and in vivo. These studies led to the idea that oxidative stress is an important factor in killing these cells. More recent attempts have made use of genetically modified mice to eliminate or over-express genesof interest. These experiments have suggested that the destruction of dopaminergic cells might be the result of the convergence of dependent and independent molecular pathways and that trigger cellular events might lead to the demise of these doparninergic cells. (C) 2001 Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:54:18