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Titolo:
Anatomy and function of dopamine receptors: understanding the pathophysiology of fluctuations in Parkinson's disease
Autore:
Wooten, GF;
Indirizzi:
Univ Virginia, Dept Neurol, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA
Titolo Testata:
PARKINSONISM & RELATED DISORDERS
fascicolo: 2, volume: 8, anno: 2001,
pagine: 79 - 83
SICI:
1353-8020(200110)8:2<79:AAFODR>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEONATAL 6-OHDA-LESIONED RATS; STRIATOPALLIDAL NEURONS; TARDIVE-DYSKINESIA; LEVODOPA; D1; GENE; D2; AGONISTS; LOCALIZATION; BRAIN;
Keywords:
dopamine receptors; coupling; sensitization; dyskinesias; short duration response;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Wooten, GF Univ Virginia, Dept Neurol, Box 800394, Charlottesville, VA 22908 USA Univ Virginia Box 800394 Charlottesville VA USA 22908 22908 USA
Citazione:
G.F. Wooten, "Anatomy and function of dopamine receptors: understanding the pathophysiology of fluctuations in Parkinson's disease", PARKINS R D, 8(2), 2001, pp. 79-83

Abstract

The principal dopamine (DA) receptors mediating the antiparkinson effects of levodopa are D1 and D2, which are anatomically and functionally segregated. We hypothesize that DA receptor-mediated effects are critical for the development of treatment-related fluctuations in Parkinson's disease (PD). We suggest that two sequential processes occur to permit the emergence of the so-called short duration response and dyskinesias: (1) functional uncoupling of D1 and D2 receptor-mediated effects with shift to the left of the dose-response curve; and, (2) sensitization of the D1-mediated striatal output due to repetitive, primarily D1 receptor stimulation by DA. These mechanisms result in excessive, pathological inhibition of basal ganglia output neurons in the GPi producing dyskinesias and the short duration response. (C)2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 03:42:59