Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE ASSOCIATION BETWEEN THE DOPAMINE D-4 RECEPTOR (D4DR) 16 AMINO-ACID REPEAT POLYMORPHISM AND NOVELTY SEEKING
Autore:
MALHOTRA AK; VIRKKUNEN M; ROONEY W; EGGERT M; LINNOILA M; GOLDMAN D;
Indirizzi:
NIMH,EXPT THERAPEUT BRANCH,DIV INTRAMURAL RES,10 CTR DR,BLDG 10,ROOM 4N212 BETHESDA MD 20892 UNIV HELSINKI,DEPT PSYCHIAT FIN-00014 HELSINKI FINLAND NIAAA,DICBR,CLIN STUDIES LAB BETHESDA MD 20892 NIAAA,DIV INTRAMURAL CLIN & BIOL RES,NEUROGENET LAB BETHESDA MD 20892
Titolo Testata:
Molecular psychiatry
fascicolo: 5, volume: 1, anno: 1996,
pagine: 388 - 391
SICI:
1359-4184(1996)1:5<388:TABTDD>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLOZAPINE; VARIANTS; GENE;
Keywords:
DOPAMINE D-4 RECEPTOR; POLYMORPHISM; PERSONALITY; ALLELE; GENOTYPE; ASSOCIATION STUDY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
A.K. Malhotra et al., "THE ASSOCIATION BETWEEN THE DOPAMINE D-4 RECEPTOR (D4DR) 16 AMINO-ACID REPEAT POLYMORPHISM AND NOVELTY SEEKING", Molecular psychiatry, 1(5), 1996, pp. 388-391

Abstract

Ebstein and colleagues have recently reported a significant association between the 7-repeat allele of the dopamine D4 receptor (D4DR) 16 amino acid repeat polymorphism and the personality trait of Novelty Seeking (NS) in 124 Israeli subjects. This study, and another study conducted in the US (although with a different personality measure) that observed a similar association, have generated wide interest in the identification of the genes involved in personality variation. We have determined D4DR genotypes in two groups of Finnish subjects; 193 psychiatrically screened normal controls and 138 alcoholic offenders and assessed NS with the Tridimensional Personality Questionnaire (TPQ). In normals, we find no significant association between NS and the 7-repeat allele despite similar allele frequencies and the use of the same personality measure as Ebstein et al. The group of alcoholic offenders havesignificantly higher NS than normals, however we fail to replicate the previous association in this group and, in fact, find a significant association in the opposite direction as previously observed. These data suggest that D4DR may require re-evaluation as a candidate gene forpersonality variation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 03:39:44