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Titolo:
Manganese mimics the action of 1-methyl-4-phenylpyridinium ion, a dopaminergic neurotoxin, in rat striatal tissue slices
Autore:
Hirata, Y; Kiuchi, K; Nagatsu, T;
Indirizzi:
RIKEN, Biomimet Control Res Ctr, Lab Genes Motor Syst, Nagoya, Aichi 4630003, Japan RIKEN Nagoya Aichi Japan 4630003 Motor Syst, Nagoya, Aichi 4630003, Japan Gifu Univ, Fac Engn, Dept Biomol Sci, Gifu 5011193, Japan Gifu Univ GifuJapan 5011193 Engn, Dept Biomol Sci, Gifu 5011193, Japan Fujita Hlth Univ, Inst Comprehens Med Sci, Div Mol Genet Neurochem, Aichi 4701101, Japan Fujita Hlth Univ Aichi Japan 4701101 net Neurochem, Aichi 4701101, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 311, anno: 2001,
pagine: 53 - 56
SICI:
0304-3940(20010921)311:1<53:MMTAO1>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; TYROSINE-HYDROXYLASE ACTIVITY; PARKINSONS-DISEASE; PC12 CELLS; MPTP; APOPTOSIS; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; INJECTION; TOXICITY; RELEASE;
Keywords:
dihydroxyphenylalanine synthesis; manganese; 1-methyl-4-phenylpyridinium ion; striatal slices;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Hirata, Y RIKEN, Biomimet Control Res Ctr, Lab Genes Motor Syst, 2271-130 Anagahora,Nagoya, Aichi 4630003, Japan RIKEN 2271-130 Anagahora Nagoya Aichi Japan 4630003 30003, Japan
Citazione:
Y. Hirata et al., "Manganese mimics the action of 1-methyl-4-phenylpyridinium ion, a dopaminergic neurotoxin, in rat striatal tissue slices", NEUROSCI L, 311(1), 2001, pp. 53-56

Abstract

Manganese and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) are known to induce neurological pathologies similar to that of parkinsonism. Previous studies performed in rat striatal slices have shown that MPTP and related compounds inhibit tyrosine hydroxylation, a rate-limiting step of dopamine biosynthesis. Here, we reported that manganese inhibited tyrosine hydroxylation in rat striatal slices. In addition, manganese caused increase in the levels of lactate indicating that aerobic glycolysis was inhibited in striatal slices. This inhibition was unique to manganese since other divalentcations, such as magnesium and zinc, did not increase lactate concentrations. These results suggest that the mechanisms by which manganese produces dysfunction of the nervous system are similar to those of MPTP. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:30:34