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Titolo:
Regional differences in the expression of corticostriatal synaptic plasticity
Autore:
Smith, R; Musleh, W; Akopian, G; Buckwalter, G; Walsh, JP;
Indirizzi:
Univ So Calif, Neurosci Program, Ethel Percy Andrus Gerontol Ctr, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 tol Ctr, Los Angeles, CA 90089 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 1, volume: 106, anno: 2001,
pagine: 95 - 101
SICI:
0306-4522(2001)106:1<95:RDITEO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; EXCITATORY STRIATAL SYNAPSES; PAIRED-PULSE FACILITATION; POSTSYNAPTIC MECHANISMS; FREQUENCY STIMULATION; NUCLEUS-ACCUMBENS; CEREBRAL-CORTEX; SPINY NEURONS; INVITRO SLICE; IN-VITRO;
Keywords:
GABA; D2 dopamine receptor; 6-hydroxydopamine; cortex; striatum; long-term depression; long-term potentiation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Walsh, JP Univ So Calif, Neurosci Program, Ethel Percy Andrus Gerontol Ctr, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 os Angeles, CA 90089 USA
Citazione:
R. Smith et al., "Regional differences in the expression of corticostriatal synaptic plasticity", NEUROSCIENC, 106(1), 2001, pp. 95-101

Abstract

Field recordings of responses to activation of corticostriatal afferents were made in coronally sectioned rat brain slices. Each recording site was categorized according to its medial to lateral and rostral to caudal position to investigate anatomical differences in synaptic plasticity. Individual responses were highly variable exhibiting extremes of tetanus induced depression and potentiation. Consequently, averaging masked the capacity of these synapses to express long-term forms of plasticity. Block of GABAA inhibition and elimination of dopaminergic input with 6-hydroxydopamine lesions both acted to increase the expression of potentiation, but again considerablevariability was observed. Separation of recordings into medial and lateralgroups revealed clear anatomical trends which contributed to the variability observed in the total sample. Paired-pulse, post-tetanic and long-term potentiation was greater in medial than in lateral groups in normal artificial cerebral spinal fluid. Similar tendencies were seen after block of GABAAreceptors with bicuculline. 6-Hydroxydopamine lesions in combination with bicuculline treatment reduced medial to lateral differences. Factoring in medial to lateral trends revealed block of GABAA receptor mediated inhibition had its greatest effect on medial corticostriatal responses and 6-hydroxydopamine lesions had their greatest effect on lateral responses. From these data we suggest anatomical variation in striatal circuitry may underlie regional differences in synaptic plasticity evoked by corticostriatal activation. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 14:26:54