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Titolo:
The effects of acute or repeated cocaine administration on nerve terminal glutamate within the rat mesolimbic system
Autore:
Kozell, LB; Meshul, CK;
Indirizzi:
Vet Adm Med Ctr, Neurocytol Lab, Res Serv, Portland, OR 97201 USA Vet Adm Med Ctr Portland OR USA 97201 b, Res Serv, Portland, OR 97201 USA Oregon Hlth Sci Univ, Dept Behav Neurosci, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 urosci, Portland, OR 97201 USA Oregon Hlth Sci Univ, Dept Pathol, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 Pathol, Portland, OR 97201 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 1, volume: 106, anno: 2001,
pagine: 15 - 25
SICI:
0306-4522(2001)106:1<15:TEOAOR>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; MEDIAL PREFRONTAL CORTEX; EXCITATORY AMINO-ACIDS; BEHAVIORAL SENSITIZATION; NUCLEUS-ACCUMBENS; EXTRACELLULAR DOPAMINE; MORPHOLOGICAL-CHANGES; TIME COURSE; ASPARTATE; AMPHETAMINE;
Keywords:
electron microscopy; immunocytochemistry; presynaptic; vesicular; sensitization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Meshul, CK Vet Adm Med Ctr, Neurocytol Lab, Res Serv, R&D29,3710 SW Vet Hosp Rd, Portland, OR 97201 USA Vet Adm Med Ctr R&D29,3710 SW Vet Hosp Rd Portland OR USA 97201
Citazione:
L.B. Kozell e C.K. Meshul, "The effects of acute or repeated cocaine administration on nerve terminal glutamate within the rat mesolimbic system", NEUROSCIENC, 106(1), 2001, pp. 15-25

Abstract

Cocaine administration alters glutamate function within several brain regions. Using quantitative electron microscopic immunocytochemistry, the present study investigted the effect of repeated intermittent cocaine (resultingin in behavioral sensitization) or acute cocaine administration on the density of glutamate immunogold labeling within nerve terminals. Rats were treated daily with saline or cocaine for 7 days. Following a 14-day withdrawalanimals were challenged with saline or cocaine. On the challenge day, most(75%) animals that received cocaine repeatedly showed a heightened locomotor response to cocaine compared to the first day of cocaine administration,and were considered behaviorally sensitized. Three days after the challenge, glutamate immunogold labeling was quantified in nerve terminals making asymmetrical synaptic contacts within the coreand shell of the nucleus accumbens, ventral tegmental area and medial prefrontal cortex. There was a decrease in such labeling in the nucleus accumbens in the group receiving acute cocaine. Locomotor activity was positively correlated with glutamate immunolabeling within nerve terminals in the nucleus accumbens core only for the cocaine-sensitized group. Nerve terminal glutamate immunolabeling in the nucleus accumbens. core, but not the shell, was increased in the non-sensitized compared to the cocaine-sensitized group. In the ventral tegmental area, glutamate immunolabeling was significantlyhigher in the cocaine-sensitized compared to the acute cocaine group. In the prefrontal cortex, there were no significant differences in glutamate immunogold labeling between treatment groups. This study indicates that acute cocaine administration significantly decreases nerve terminal glutamate immunoreactivity in the nucleus accumbens. Wesuggest that sensitization results in differential changes in the nucleus accumbens core versus the shell, and may alter presynaptic mechanisms regulating glutamate release or re-uptake in the core. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

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Documento generato il 03/04/20 alle ore 08:20:21