Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Stimulus-dependence of NO-mediated neuronal activation: a Fos expression study in the hippocampus and cortex of lactating rats
Autore:
Okere, CO; Higuchi, T; Kaba, H;
Indirizzi:
Kochi Med Sch, Dept Physiol, Nanko Ku, Kochi 7838505, Japan Kochi Med SchKochi Japan 7838505 hysiol, Nanko Ku, Kochi 7838505, Japan Fukui Med Univ, Dept Physiol, Fukui 9101193, Japan Fukui Med Univ Fukui Japan 9101193 v, Dept Physiol, Fukui 9101193, Japan
Titolo Testata:
NEUROREPORT
fascicolo: 13, volume: 12, anno: 2001,
pagine: 2859 - 2864
SICI:
0959-4965(20010917)12:13<2859:SONNAA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; INTRACEREBROVENTRICULAR INJECTION; GENE-EXPRESSION; L-ARGININE; BRAIN; POTENTIATION; INDUCTION; PROTEIN; SYSTEM;
Keywords:
cortex; Fos; hippocampus; nitric oxide; N-omega-nitro-L-arginine; lactation; sodium nitroprusside; suckling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Okere, CO Med Coll Penn & Hahnemann Univ, Sch Med, Dept Neurobiol & Anat, 2900 QueenLane, Philadelphia, PA 19129 USA Med Coll Penn & Hahnemann Univ 2900 Queen Lane Philadelphia PA USA 19129
Citazione:
C.O. Okere et al., "Stimulus-dependence of NO-mediated neuronal activation: a Fos expression study in the hippocampus and cortex of lactating rats", NEUROREPORT, 12(13), 2001, pp. 2859-2864

Abstract

We investigated how simultaneous manipulation of suckling and i.c.v. injection of nitric oxide (NO)-related pharmacological agents affect Fos activation in the hippocampus and cortex of lactating rats. Dams received drugs orvehicle injection just prior to reunion with their pups following a 12 h separation and Fos protein activation was examined after 2 h of suckling. Inconscious dams, sodium nitroprusside (SNP, an NO donor) significantly activated Fos expression in the hippocampus and cortex compared with vehicle oran NO synthase inhibitor. Urethane anaesthesia abolished Fos expression inthe cortex, but not in the hippocampus following simultaneous SNP injection and resumption of suckling. Fos activation in the hippocampus and cortex was significantly attenuated when SNP was injected alone (without dam-pups reunion after separation). Coincident injection of SNP with a NO synthase inhibitor abolished all Fos activation in the hippocampus and cortex. In chronically lactating rats (without any interruption of suckling) SNP injection failed to activate any Fos expression. These observations underscore the importance of stimulus modality in revealing the dynamics of NO-mediated neuronal function within a discrete tissue entity such as the hippocampus or the cortex, which may be relevant to other regions of the brain. NeuroReport 12:2859-2864 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:21:37