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Titolo:
Language representation in a patient with a dominant right hemisphere: fMRI evidence for an intrahemispheric reorganisation
Autore:
Seghier, M; Lazeyras, F; Momjian, S; Annoni, JM; de Tribolet, N; Khateb, A;
Indirizzi:
Univ Hosp Geneva, Dept Neurol, Neuropsychol Unit, CH-1211 Geneva 14, Switzerland Univ Hosp Geneva Geneva Switzerland 14 t, CH-1211 Geneva 14, Switzerland Univ Hosp Geneva, Dept Radiol, CH-1211 Geneva, Switzerland Univ Hosp Geneva Geneva Switzerland CH-1211 CH-1211 Geneva, Switzerland Univ Hosp Geneva, Dept Neurosurg, CH-1211 Geneva 14, Switzerland Univ HospGeneva Geneva Switzerland 14 g, CH-1211 Geneva 14, Switzerland Univ Hosp Geneva, Dept Neurol, Funct Brain Mapping Lab, CH-1211 Geneva 14,Switzerland Univ Hosp Geneva Geneva Switzerland 14 ab, CH-1211 Geneva 14,Switzerland Univ Geneva, Plurifac Program Cognit Neurosci, CH-1211 Geneva 4, Switzerland Univ Geneva Geneva Switzerland 4 Neurosci, CH-1211 Geneva 4, Switzerland
Titolo Testata:
NEUROREPORT
fascicolo: 13, volume: 12, anno: 2001,
pagine: 2785 - 2790
SICI:
0959-4965(20010917)12:13<2785:LRIAPW>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL ARTERIOVENOUS MALFORMATION; FUNCTIONAL MRI; POSTSTROKE APHASIA; BRAIN ACTIVITY; WADA TEST; RECOVERY; SPECIALIZATION; ACTIVATION; PLASTICITY; LESIONS;
Keywords:
AVM; frontal cortex; functional magnetic resonance imaging; functional recovery; phonologic and semantic tasks; right hemisphere;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Khateb, A Univ Hosp Geneva, Dept Neurol, Neuropsychol Unit, 24 Rue Michelidu Crest,CH-1211 Geneva 14, Switzerland Univ Hosp Geneva 24 Rue Micheli duCrest Geneva Switzerland 14
Citazione:
M. Seghier et al., "Language representation in a patient with a dominant right hemisphere: fMRI evidence for an intrahemispheric reorganisation", NEUROREPORT, 12(13), 2001, pp. 2785-2790

Abstract

Studies have suggested that congenital left hemispheric (LH) frontal arteriovenous malformations (AVMs) are associated with an early transfer of language to right hemisphere (RH) frontal regions. The question remains whethersuch anatomo-functional reorganisation is due to RH compensatory abilitiesor to a general principle of lateral shift. In this study, we used fMRI language paradigms to investigate the case of a patient presenting aphasic symptoms following an haemorrhage due to a right frontal AVM. Prior to surgery, fMRI showed that language processing was confined to the RH, suggesting that language had not shifted during childhood from this congenitally dominant RH to the LH. After surgery, the patient presented severe aphasia that recovered to presurgical level within 70 days. At this time, fMRI showed that language tasks were still not associated with activations in the LH. These results suggest that the principles of early cerebral reorganisation after congenital lesions may differ in the RH and the LH. In addition, they support the idea that efficient restoration of language is achieved if a sufficiently large neuronal network is preserved around the lesion. NeuroReport12:2785-2790 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:08:20