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Titolo:
Co-association of parkin and alpha-synuclein
Autore:
Choi, P; Golts, N; Snyder, H; Chong, M; Petrucelli, L; Hardy, J; Sparkman, D; Cochran, E; Lee, JM; Wolozin, B;
Indirizzi:
Loyola Univ, Med Ctr, Dept Pharmacol, Maywood, IL 60153 USA Loyola Univ Maywood IL USA 60153 r, Dept Pharmacol, Maywood, IL 60153 USA Loyola Univ, Med Ctr, Dept Pathol, Maywood, IL 60153 USA Loyola Univ Maywood IL USA 60153 Ctr, Dept Pathol, Maywood, IL 60153 USA Mayo Clin, Dept Pharmacol, Jacksonville, FL 32224 USA Mayo Clin Jacksonville FL USA 32224 Pharmacol, Jacksonville, FL 32224 USA Rush Presbyterian St Lukes Med Ctr, Dept Pathol, Chicago, IL 60612 USA Rush Presbyterian St Lukes Med Ctr Chicago IL USA 60612 ago, IL 60612 USA
Titolo Testata:
NEUROREPORT
fascicolo: 13, volume: 12, anno: 2001,
pagine: 2839 - 2843
SICI:
0959-4965(20010917)12:13<2839:COPAA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECESSIVE JUVENILE PARKINSONISM; UBIQUITIN-PROTEIN LIGASE; LEWY BODIES; IN-VITRO; DISEASE; GENE; MUTATIONS; ONSET;
Keywords:
aggregation; chaperone; immunoprecipitation; Lewy body; pathology; ubiquitination;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Wolozin, B Loyola Univ, Med Ctr, Dept Pharmacol, Bldg 102,Rm 3634,2160 S 1st Ave, Maywood, IL 60153 USA Loyola Univ Bldg 102,Rm 3634,2160 S 1st Ave Maywood IL USA 60153
Citazione:
P. Choi et al., "Co-association of parkin and alpha-synuclein", NEUROREPORT, 12(13), 2001, pp. 2839-2843

Abstract

Parkin and alpha -synuclein are two proteins that are associated with the pathophysiology of Parkinson's disease (PD). Parkin is present in Lewy bodies and axonal spheroids in brains affected by PD, and mutations in parkin cause hereditary forms of Parkinsonism. alpha -Synuclein is a major component of Lewy bodies and is associated with rare cases of PD. We now show that Parkin binds to alpha -synuclein, including conditions associated with alpha -synuclein aggregation, Parkin and alpha -synuclein complexes were observed in BE-M17 cells under basal conditions, in BE-M17 cells under oxidative conditions and in brains from control or PD donors. Double staining of PD brains shows parkin and alpha -synuclein co-localize to the same pathological structures (both Lewy bodies and axonal spheroids). These results suggestthat Parkin interacts with alpha -synuclein and could contribute to the pathophysiology of PD more generally than was previously considered. NeuroReport 12:2839-2843 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 18:51:46