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Titolo:
Dietary fat up-regulates the apolipoprotein E mRNA level in the Zucker lean rat brain
Autore:
Knight, DS; Mahajan, DK; Qiao, XX;
Indirizzi:
LSUHSC, Dept Cellular Biol & Anat, Shreveport, LA 71130 USA LSUHSC Shreveport LA USA 71130 ular Biol & Anat, Shreveport, LA 71130 USA LSUHSC, Dept Obstet & Gynecol, Shreveport, LA 71130 USA LSUHSC ShreveportLA USA 71130 Obstet & Gynecol, Shreveport, LA 71130 USA
Titolo Testata:
NEUROREPORT
fascicolo: 14, volume: 12, anno: 2001,
pagine: 3111 - 3115
SICI:
0959-4965(20011008)12:14<3111:DFUTAE>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPOTHALAMIC NEUROPEPTIDE-Y; GALANIN GENE-EXPRESSION; ALZHEIMERS-DISEASE; PROTEIN; CHOLESTEROL; NUCLEUS; DENSITY; ISOFORM; LEPTIN;
Keywords:
Alzheimer's disease; apolipoprotein E; high-fat diet; leptin receptor; Zucker;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Knight, DS LSUHSC, Dept Cellular Biol & Anat, 1501 Kings Highway,POB 33932, Shreveport, LA 71130 USA LSUHSC 1501 Kings Highway,POB 33932 Shreveport LA USA 71130 USA
Citazione:
D.S. Knight et al., "Dietary fat up-regulates the apolipoprotein E mRNA level in the Zucker lean rat brain", NEUROREPORT, 12(14), 2001, pp. 3111-3115

Abstract

High-fat diet alters apo E-dependent processing of beta -amyloid precursorprotein. Here we have evaluated the effects of dietary fat on brain apo E mRNA in Zucker lean and obese rats. After similar to2 months on a high-fat diet, there was significant up-regulation of brain apo E mRNA in the Zuckerlean rat in parallel with weight gain. Densitometric quantification revealed a 17% increase in apo E mRNA in the brains of lean rats fed high-fat diet compared with those of lean rats fed rat chow. No significant difference in brain apo E mRNA of Zucker obese rats fed different diets was found. These results suggest that dietary fat alters brain apo E levels, which may beregulated, in part, through the leptin receptor. NeuroReport 12:3111-3115 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 21:46:27