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Titolo:
Balance control and posture in anxious mice improved by SSRI treatment
Autore:
Venault, P; Rudrauf, D; Lepicard, EM; Berthoz, A; Jouvent, R; Chapouthier, G;
Indirizzi:
CHU Pitie Salpetriere, CNRS, UMR Vulnerabil Adaptat & Psychopathol 7593, F-75013 Paris, France CHU Pitie Salpetriere Paris France F-75013 l 7593, F-75013 Paris, France Coll France, CNRS, UMR LPPA C9950, F-75005 Paris, France Coll France Paris France F-75005 , UMR LPPA C9950, F-75005 Paris, France
Titolo Testata:
NEUROREPORT
fascicolo: 14, volume: 12, anno: 2001,
pagine: 3091 - 3094
SICI:
0959-4965(20011008)12:14<3091:BCAPIA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN REUPTAKE INHIBITORS; FORCED SWIMMING TEST; ANIMAL-MODELS; ANXIOLYTIC DRUGS; PANIC ATTACKS; ANXIETY; ANTIDEPRESSANT; DEPRESSION; RECEPTORS;
Keywords:
anxiety; balance; inbred strains of mice; posture; SSRI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Venault, P CHU Pitie Salpetriere, CNRS, UMR Vulnerabil Adaptat & Psychopathol 7593, 91 Bd Hop, F-75013 Paris, France CHU Pitie Salpetriere 91 Bd Hop Paris France F-75013 s, France
Citazione:
P. Venault et al., "Balance control and posture in anxious mice improved by SSRI treatment", NEUROREPORT, 12(14), 2001, pp. 3091-3094

Abstract

A task requiring dynamic postural stabilisation during locomotion in a conflicting visual vestibular environment (rotating beam), has been devised toassess anxiety-related balance impairments and postural changes in mice. The model, already validated with acutely administered diazepam, was used toassess the action of two chronically administered selective serotonin reuptake inhibitors (SSRIs), fluoxetine and paroxetine. On three behavioural measures (imbalance, elevation of trunk and angle of tail), observed in anxious BALB/cByJ mice, both compounds had the same diazepam-like effects: reduction in number of imbalances, higher elevation of trunk and increase in tail angle. These data suggest, for the first time, that SSRIs should be useful in the treatment of anxiety-induced balance impairments. NeuroReport 12:3091-3094 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/02/20 alle ore 08:04:20