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Titolo:
Differential in vivo internalization of MOR-1 and MOR-1C by morphine
Autore:
Abbadie, C; Pasternak, GW;
Indirizzi:
Mem Sloan Kettering Canc Ctr, Lab Mol Neuropharmacol, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA
Titolo Testata:
NEUROREPORT
fascicolo: 14, volume: 12, anno: 2001,
pagine: 3069 - 3072
SICI:
0959-4965(20011008)12:14<3069:DIVIOM>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MU-OPIOID RECEPTOR; AGONIST-MEDIATED INTERNALIZATION; INTRACELLULAR TRAFFICKING; EXPRESSION; BRAIN; RESENSITIZATION; ENDOCYTOSIS; VARIANTS; ISOFORM; NEURONS;
Keywords:
central nervous system; immunohistochemistry; internalization; lateral septum; MOP1C; MOR-1C; mouse; opioid receptor; splice variant;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Pasternak, GW Mem Sloan Kettering Canc Ctr, Lab Mol Neuropharmacol, 1275 York Ave, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr 1275 York Ave New York NY USA 10021
Citazione:
C. Abbadie e G.W. Pasternak, "Differential in vivo internalization of MOR-1 and MOR-1C by morphine", NEUROREPORT, 12(14), 2001, pp. 3069-3072

Abstract

The mu opioid receptor MOR-1 is internalized by many mu agonists, but not morphine. To see whether differences in the intracellular carboxy terminus influences internalization, we examined internalization of a splice variantof the mu opioid receptor, MOR-1C, in the lateral septum of the mouse in vivo. Following intracerebroventricular (i.c.v.) saline treatment, MOR-1C-like immunoreactivity (L1) within neurons in naive mice was found predominantly in clusters close to the plasma membrane. Following either intracerebroventricular [D-Ala(2),MePhe(4),Gly(ol)(5)]enkephalin (DAMGO) or morphine, MOR-1C-L1 clustered into endosomes in the cytoplasm. This effect was suppressed by prior administration of the opioid antagonist naloxone. In contrast, only DAMGO, and not morphine, internalized MOR-1-L1. These results illustrate differences in internalization between two MOR-1 variants that have alternative splicing at the COOH terminus. NeuroReport 12:3069-3072 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 04:33:44