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Titolo:
A1 adenosine receptor activation inhibits neurite process formation by rhokinase-mediated pathways
Autore:
Thevananther, S; Rivera, A; Rivkees, SA;
Indirizzi:
Yale Univ, Sch Med, Dept Pediat, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 ed, Dept Pediat, New Haven, CT 06520 USA
Titolo Testata:
NEUROREPORT
fascicolo: 14, volume: 12, anno: 2001,
pagine: 3057 - 3063
SICI:
0959-4965(20011008)12:14<3057:AARAIN>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; RAT PC12 CELLS; NA-H EXCHANGE; PROTEIN-KINASE; SIGNAL-TRANSDUCTION; FOCAL ADHESIONS; SMALL GTPASE; PC-12 CELLS; ROK-ALPHA; RETRACTION;
Keywords:
adenosine; PC12; MAP kinase; neuron; Rho A; Rho kinase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Rivkees, SA Yale Univ, Sch Med, Dept Pediat, POB 208081, New Haven, CT 06520 USA Yale Univ POB 208081 New Haven CT USA 06520 aven, CT 06520 USA
Citazione:
S. Thevananther et al., "A1 adenosine receptor activation inhibits neurite process formation by rhokinase-mediated pathways", NEUROREPORT, 12(14), 2001, pp. 3057-3063

Abstract

A1 adenosine receptors (A1ARs) are expressed in the brain during critical periods of neurogenesis and neuronal differentiation. To examine influencesof A1AR activation on neuronal development we studied the effects of A1AR activation on process growth in PC12 cells expressing A1ARs and in primary cultures of cortical and hippocampal neurons. In PC12 cells, we found that A1AR activation potently inhibited nerve growth factor (NGF)-induced neurite growth and induced stress fiber formation. A1ARs action was not mediated by inhibition of p44/42 MAP kinase activity, as inhibition of MEK/MAP kinase had no effects on A1AR action. When Rho kinase activity was blocked, A1ARagonists no longer inhibited neurite growth and stress fiber formation wasblocked. In neurons, A1AR activation also inhibited process growth, and A1AR action was also mediated by Rho kinase. These data show that A1AR activation inhibits neurite growth and that the inhibitory effects of A1AR are dependent on Rho kinase. NeuroReport 12:3057-3063 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:43:07