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Titolo:
Lead inhibition of NMDA channels in native and recombinant receptors
Autore:
Gavazzo, P; Gazzoli, A; Mazzolini, M; Marchetti, C;
Indirizzi:
CNR, Ist Cibernet & Biofis, I-16149 Genoa, Italy CNR Genoa Italy I-16149CNR, Ist Cibernet & Biofis, I-16149 Genoa, Italy
Titolo Testata:
NEUROREPORT
fascicolo: 14, volume: 12, anno: 2001,
pagine: 3121 - 3125
SICI:
0959-4965(20011008)12:14<3121:LIONCI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBELLAR GRANULE CELLS; D-ASPARTATE RECEPTOR; K+-INDUCED DEPOLARIZATION; DIFFERENTIAL EXPRESSION; HIPPOCAMPAL-NEURONS; MECHANISMS; SENSITIVITY; CURRENTS; DEFICITS; AFFINITY;
Keywords:
cerebellar granule neurons; glutamate-activated channels; heavy metals; neurotoxicity; NMDA receptor subunits;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Marchetti, C CNR, Ist Cibernet & Biofis, I-16149 Genoa, Italy CNR Genoa Italy I-16149 rnet & Biofis, I-16149 Genoa, Italy
Citazione:
P. Gavazzo et al., "Lead inhibition of NMDA channels in native and recombinant receptors", NEUROREPORT, 12(14), 2001, pp. 3121-3125

Abstract

NMDA channels are key targets for lead (Pb2+) neurotoxicity and Pb2+-induced inhibition of NMDA current is age- and subunit-dependent. In rat cerebellar granule cells maintained in high KCl, glycine affinity as well as sensitivity to ifenprodil change significantly with the days in vitro, indicating a reduction of NR2B subunit expression. Pb2+ blocked NMDA current with IC50 similar to4 muM and this effect decreased significantly during the second week in vitro. In Xenopus laevis oocytes expressing recombinant NRI-NR2A,NRI-NR2B or NRI-NR2C receptors, Pb2+ inhibited glutamate-activated currents with IC50 of 3.3, 2,5 and 4.7 muM respectively. These data indicate that Pb2+ action is dependent on subunit composition and suggest that down-regulation of the NR2B subunit is correlated to a diminished sensitivity to Pb2inhibition. NeuroReport 12:3121-3125 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 19/01/20 alle ore 14:26:10