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Titolo:
Endogenous nociceptin signaling and stress-induced analgesia
Autore:
Rizzi, A; Marzola, G; Bigoni, R; Guerrini, R; Salvadori, S; Mogil, JS; Regoli, D; Calo, G;
Indirizzi:
Univ Modena, Pharmacol Sect, Dept Expt & Clin Med, I-41100 Modena, Italy Univ Modena Modena Italy I-41100 Expt & Clin Med, I-41100 Modena, Italy Dept Pharmaceut Sci, I-44100 Ferrara, Italy Dept Pharmaceut Sci Ferrara Italy I-44100 ut Sci, I-44100 Ferrara, Italy Ctr Biotechnol, I-44100 Ferrara, Italy Ctr Biotechnol Ferrara Italy I-44100 Biotechnol, I-44100 Ferrara, Italy McGill Univ, Dept Psychol, Montreal, PQ H3A 1B1, Canada McGill Univ Montreal PQ Canada H3A 1B1 chol, Montreal, PQ H3A 1B1, Canada
Titolo Testata:
NEUROREPORT
fascicolo: 14, volume: 12, anno: 2001,
pagine: 3009 - 3013
SICI:
0959-4965(20011008)12:14<3009:ENSASA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORPHANIN FQ; RECEPTOR; FQ/NOCICEPTIN; MICE; PEPTIDE;
Keywords:
mouse tail-withdrawal assay (TW); nociceptin/orphanin FQ (NC); [Nphe(1)]NC(I-13)NH2; OP4 receptor; swim stress-induced analgesia (SIA);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Calo, G Univ Modena, Pharmacol Sect, Dept Expt & Clin Med, Via Fossato Mortara 17,I-41100 Modena, Italy Univ Modena Via Fossato Mortara 17 Modena Italy I-41100 na, Italy
Citazione:
A. Rizzi et al., "Endogenous nociceptin signaling and stress-induced analgesia", NEUROREPORT, 12(14), 2001, pp. 3009-3013

Abstract

Nociceptin/orphanin FQ (NC) and its receptor (OP4) have been implicated inpain transmission. The aim of the present study was to investigate the role of the NC/OP4 system in stress-induced analgesia (SIA). The tail-withdrawal assay was performed in mice stressed by forced swimming in water at 15 degreesC (high severity swims) or 32 degreesC (low severity swims). High severity swims produced a naloxone-insensitive antinociceptive effect which was blocked by supraspinal NC (I nmol). The selective OP4 receptor antagonist, [Nphe(1)]]NC(-13)NH2 (30 nmol), was inactive by itself, but prevented theeffect of NC. Low severity swims produced a milder analgesic effect that was partially antagonized by naloxone, completely blocked by NC and potentiated by [Nphe(1)]NC(- 13)NH2. These findings confirm the anti-analgesic roleof supraspinal NC and suggest that endogenous NC signaling counteracts theopioid component of SIA. NeuroReport 12:3009-3013 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:49:29