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Titolo:
Transtympanic tetrodotoxin alters the VOR and Fos labeling in the vestibular complex
Autore:
Saxon, DW; Anderson, JH; Beitz, AJ;
Indirizzi:
Indiana Univ Sch Med, Evansville Ctr Med Educ, Dept Anat & Cell Biol, Evansville, IN 47712 USA Indiana Univ Sch Med Evansville IN USA 47712 ol, Evansville, IN 47712 USA Univ Minnesota, Dept Otolaryngol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 ryngol, Minneapolis, MN 55455 USA Univ Minnesota, Dept Vet Pathobiol, St Paul, MN 55108 USA Univ Minnesota St Paul MN USA 55108 Vet Pathobiol, St Paul, MN 55108 USA
Titolo Testata:
NEUROREPORT
fascicolo: 14, volume: 12, anno: 2001,
pagine: 3051 - 3055
SICI:
0959-4965(20011008)12:14<3051:TTATVA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
UNILATERAL LABYRINTHECTOMY; GUINEA-PIG; BRAIN-STEM; RAT-BRAIN; C-FOS; NERVOUS-SYSTEM; EXPRESSION; COMPENSATION; NUCLEUS; BLOCKADE;
Keywords:
inner ear; nystagmus; tetrodotoxin; vestibular;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Saxon, DW Indiana Univ Sch Med, Evansville Ctr Med Educ, Dept Anat & Cell Biol, 8600Univ Blvd, Evansville, IN 47712 USA Indiana Univ Sch Med 8600 Univ Blvd Evansville IN USA 47712 USA
Citazione:
D.W. Saxon et al., "Transtympanic tetrodotoxin alters the VOR and Fos labeling in the vestibular complex", NEUROREPORT, 12(14), 2001, pp. 3051-3055

Abstract

The sodium channel blocker tetrocdotoxin (TTX) is an effective tool for blockade of action potentials. Unilateral transtympanic administration of 3 mM TTX produced behavioral symptoms similar to those following unilateral peripheral vestibular ablation. Complete resolution of visible symptoms occurred between 48 and 72 h post-TTX. Eye-coil recordings indicated a spontaneous nystagmus and a decrease in the VOR in TTX-treated animals. Neuronal activity in the central vestibular complex (VC), as monitored with Fos immunocytochemistry, revealed an asymmetric pattern of Fos labeling in the medial,inferior and superior vestibular nuclei and the prepositus hypoglossal nucleus. Although the spatio-temporal pattern of Fos labeling was consistent and reproducible at each time-point, changes were noted among time-points. Transient blockade with TTX may be useful for studying the central vestibular response to recurrent or episodic vestibular disruption in the intact system. NeuroReport 12:3051-3055 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 09:51:16