Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Correlating multiple MRI parameters with clinical features: an attempt to define a new strategy in multiple sclerosis
Autore:
Tourbath, A; Stievenart, JL; Abanou, A; Fontaine, B; Cabanis, EA; Lyon-Caen, O;
Indirizzi:
Hop La Pitie Salpetriere, F-75651 Paris 13, France Hop La Pitie Salpetriere Paris France 13 riere, F-75651 Paris 13, France Ctr Hosp Natl Ophtalmol XV XX, Serv Neuroradiol, Paris, France Ctr Hosp Natl Ophtalmol XV XX Paris France v Neuroradiol, Paris, France Fac Med Pitie Salpetriere, INSERM, U546, Paris, France Fac Med Pitie Salpetriere Paris France ere, INSERM, U546, Paris, France Hop Beaujon, Serv Biophys & Med Nucl, Clichy, France Hop Beaujon Clichy France ujon, Serv Biophys & Med Nucl, Clichy, France
Titolo Testata:
NEURORADIOLOGY
fascicolo: 9, volume: 43, anno: 2001,
pagine: 712 - 720
SICI:
0028-3940(200109)43:9<712:CMMPWC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
APPEARING WHITE-MATTER; MAGNETIC-RESONANCE SPECTROSCOPY; DISEASE-ACTIVITY; IMAGING LESIONS; DISABILITY; DIFFUSION; ATROPHY; INVIVO;
Keywords:
multiple sclerosis; magnetisation transfer; diffusion; spectroscopy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Tourbath, A Hop La Pitie Salpetriere, 47 Blvd Hop, F-75651 Paris 13, France Hop La Pitie Salpetriere 47 Blvd Hop Paris France 13 , France
Citazione:
A. Tourbath et al., "Correlating multiple MRI parameters with clinical features: an attempt to define a new strategy in multiple sclerosis", NEURORADIOL, 43(9), 2001, pp. 712-720

Abstract

MRI is the most powerful imaging technique in managing patients with suspected or confirmed multiple sclerosis (MS). However, conventional MRI variables show nonspecific abnormalities weakly correlated with clinical progression of the disease. New techniques, now routinely available, offer better characterisation of the pathophysiology. We combined conventional MRI, including lesion load, contrast enhancement and "black holes" with magnetisationtransfer and diffusion-weighted imaging and localised proton MR spectroscopy (MRS) to study their relationship with disability, course and duration of MS. The variables that were the most significantly linked to the course of the disease (relapsing remitting versus secondary progressive) were lesion load, mean overall magnetisation transfer ratio and apparent diffusion coefficient (MGADC), the percentage of ADC in (PADCIMD), and out of (PADCOMD)modal distribution, and the ratio N-acetylaspartate and creatine-containing compounds on MRS of the centrum semiovale. MGADC and PADCIMD were the independent factors most related to disability and duration of disease. Combining MRI techniques is clinically relevant and feasible for studies of MS and may be applied to other diseases of the central nervous system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:36:24