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Titolo:
Possible relationship between combined plasma concentrations of risperidone plus 9-hydroxyrisperidone and extrapyramidal symptoms - Preliminary study
Autore:
Yoshimura, R; Ueda, N; Nakamura, J;
Indirizzi:
Univ Occupat & Environm Hlth, Sch Med, Dept Psychiat, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555 8555, Japan
Titolo Testata:
NEUROPSYCHOBIOLOGY
fascicolo: 3, volume: 44, anno: 2001,
pagine: 129 - 133
SICI:
0302-282X(2001)44:3<129:PRBCPC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOCHROMES P450 2D6; SCHIZOPHRENIC-PATIENTS; ANTIPSYCHOTIC-DRUGS; RECEPTOR OCCUPANCY; DOUBLE-BLIND; HALOPERIDOL; MULTICENTER; METABOLISM; EFFICACY; PLACEBO;
Keywords:
risperidone; 9-hydroxyrisperidone; extrapyramidal symptoms;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Yoshimura, R Univ Occupat & Environm Hlth, Sch Med, Dept Psychiat, 1-1 Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth 1-1 Yahatanishi Ku Kitakyushu Fukuoka Japan 8078555
Citazione:
R. Yoshimura et al., "Possible relationship between combined plasma concentrations of risperidone plus 9-hydroxyrisperidone and extrapyramidal symptoms - Preliminary study", NEUROPSYCHB, 44(3), 2001, pp. 129-133

Abstract

We investigated the relationships between extrapyramidal symptoms (EPS) induced by risperidone, the dosage of risperidone and the combined plasma concentrations of risperidone plus its active metabolite, 9-hydroxyrisperidone, in 20 schizophrenic patients. There was a positive correlation between the scores on the Simpson and Angus Scale and both the dosage of risperidone and the sum of the plasma levels of risperidone and 9-hydroxyrisperidone. These results suggest that EPS induced by risperidone increase in conjunction with both the dosage of risperidone and the total plasma concentrations of the parent compound and its active metabolite. Copyright (C) 2001 S. KargerAG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/11/19 alle ore 02:39:18