Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Correlation between platelet alpha(2)-adrenoreceptors and symptom severityin major depression
Autore:
Marazziti, D; Baroni, S; Masala, I; Di Nasso, E; Giannaccini, G; Betti, L; Lucacchini, A; Cassano, GB;
Indirizzi:
Univ Pisa, Dipartimento Psichiatria Neurobiol Farmacol & Bio, I-56100 Pisa, Italy Univ Pisa Pisa Italy I-56100 urobiol Farmacol & Bio, I-56100 Pisa, Italy
Titolo Testata:
NEUROPSYCHOBIOLOGY
fascicolo: 3, volume: 44, anno: 2001,
pagine: 122 - 125
SICI:
0302-282X(2001)44:3<122:CBPAAS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCUS-COERULEUS; ALPHA-2-ADRENERGIC RECEPTORS; AFFECTIVE-DISORDERS; SUICIDE VICTIMS; BINDING; CATECHOLAMINES; YOHIMBINE; DENSITY;
Keywords:
norepinephrine; depression; alpha(2)-adrenoreceptors; [H-3]rauwolscine binding; Hamilton Rating Scale for Depression (HRSD);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Marazziti, D Univ Pisa, Dipartimento Psichiatria Neurobiol Farmacol & Bio,Via Roma 67,I-56100 Pisa, Italy Univ Pisa Via Roma 67 Pisa Italy I-56100 I-56100 Pisa, Italy
Citazione:
D. Marazziti et al., "Correlation between platelet alpha(2)-adrenoreceptors and symptom severityin major depression", NEUROPSYCHB, 44(3), 2001, pp. 122-125

Abstract

Background. Abnormalities in different parameters of the norepinephrine system have been widely described in major depression. The presence of alpha (2)-adrenoreceptors in blood platelets, similar to,those in the brain, prompted us to evaluate them in depressed patients, as compared with healthy controls. Methods. Fifteen outpatients affected by major depression, according to DSM IV criteria, and 15 comparable healthy control subjects, were included in the study. The, alpha (2)-adrenoreceptors were measured by means ofthe specific binding of DSM IV rauwolscine, a high ly selective antagonistfor th is receptor sub-type. The severity of depression was assessed by means of the Hamilton Rating Scale for Depression: (HRSD). Results. The results did not show any difference in [H-3]rauwolscine binding parameters (B-max and K-d) between patients and controls. However, in! the patients, a significant and positive correlation between B-max, which measures the density of the receptors, and HRSD total score was detected. Conclusions: Therefore, although no change in alpha (2)-adrenoreceptors seems to occur in major depression, the density of these receptors would seem to be related to the severity of depressive symptoms. Copyright (C) 2001 S. KargerAG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:09:34