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Titolo:
Blockade of the metabotropic glutamate receptor subtype 5 (mGluR5) produces antiparkinsonian-like effects in rats
Autore:
Ossowska, K; Konieczny, J; Wolfarth, S; Wieronska, J; Pilc, A;
Indirizzi:
Polish Acad Sci, Inst Pharmacol, Dept Neuropsychopharmacol, PL-31343 Krakow, Poland Polish Acad Sci Krakow Poland PL-31343 harmacol, PL-31343 Krakow, Poland Polish Acad Sci, Inst Pharmacol, Dept Neurobiol, PL-31343 Krakow, Poland Polish Acad Sci Krakow Poland PL-31343 eurobiol, PL-31343 Krakow, Poland
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 4, volume: 41, anno: 2001,
pagine: 413 - 420
SICI:
0028-3908(200109)41:4<413:BOTMGR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY AMINO-ACIDS; RESERPINE-TREATED RAT; NMDA RECEPTOR; PARKINSONS-DISEASE; MUSCLE TONE; SUBTHALAMIC NUCLEUS; STRIATAL NEURONS; BASAL GANGLIA; MESSENGER-RNA; GLYCINE SITE;
Keywords:
mGluR5 glutamate receptors; 2-methyl-6-(phenylethynyl)pyridine; antiparkinsonian-like effects; locomotor activity; catalepsy; muscle rigidity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Ossowska, K Polish Acad Sci, Inst Pharmacol, Dept Neuropsychopharmacol, 12Smetna St, PL-31343 Krakow, Poland Polish Acad Sci 12 Smetna St Krakow Poland PL-31343 w, Poland
Citazione:
K. Ossowska et al., "Blockade of the metabotropic glutamate receptor subtype 5 (mGluR5) produces antiparkinsonian-like effects in rats", NEUROPHARM, 41(4), 2001, pp. 413-420

Abstract

The aim of the present study was to examine a potential beneficial effect of the blockade of metabotropic glutamate receptor subtype 5 (mGluR5) by the selective non-competitive antagonist, 2-methyl-6-(phenylethynyl)pyridine (MPEP), in models of parkinsonian symptoms in rats. Haloperidol, 0.25, 0.5 and 1 mg/kg ip, was used to induce hypolocomotion, catalepsy and muscle rigidity, respectively. The locomotor activity was estimated by an open-field test, the catalepsy - by a 9-cm cork test. The muscle rigidity was measuredas an increased resistance of a hind leg to passive extension and flexion at the ankle joint. Additionally, increases in the electromyographic activity were recorded in the gastrocnemius and tibialis anterior muscles. MPEP (1.0-10 mg/kg ip) inhibited the muscle rigidity, electromyographic activity,hypolocomotion and catalepsy induced by haloperidol. MPEP administered alone (5 mg/kg ip) did not induce catalepsy, nor did it influence the muscle tone or locomotor activity in rats. The present results suggest that blockade of mGluR5 receptors may be important to amelioration of both parkinsonianakinesia and muscle rigidity. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:21:05